Influence of disodium etidronate on Paget's disease of bone
| dc.contributor.author | Muir, H. G. | en_ZA |
| dc.contributor.author | Schabort, I. | en_ZA |
| dc.contributor.author | Hough, F. S. | en_ZA |
| dc.date.accessioned | 2011-03-18T14:57:27Z | |
| dc.date.available | 2011-03-18T14:57:27Z | |
| dc.date.issued | 1987 | |
| dc.description | CITATION: Muir, H. G., Schabort, I. & Hough, F. S. 1987. Influence of disodium etidronate on Paget's disease of bone. South African Medical Journal, 72:470-472. | |
| dc.description | The original publication is available at http://www.samj.org.za | |
| dc.description.abstract | The use of agents that decrease bone resorption, notably the calcitonins, diphosphonates and mithramycin, has been shown to result in symptomatic and/or biochemical improvement in patients with Paget's disease of bone (osteitis deformans). The effects of short-term (6 months), low-dose (5 mg/kg body mass/d) etidronate disodium, a diphosphonate compound at present subject to registration in this country, on the clinical and laboratory manifestations of this disorder were examined. Marked symptomatic improvement was noted in 70% of patients, while biochemical parameters of bone turnover, namely serum alkaline phosphatase level (44%) and urine hydroxyproline excretion (56%), decreased significantly (P less than 0.001). A technetium-99m bone scan revealed an impressive reduction in uptake of isotope in 50% of patients. The drug was well tolerated and no adverse reactions (clinical, biochemical or haematological) were evident. It is concluded that short-term low-dose etidronate disodium affords a convenient and effective therapeutic alternative in patients with symptomatic Paget's disease. | |
| dc.description.version | Publisher’s version | |
| dc.format.extent | 3 pages | |
| dc.identifier.issn | 2078-5135 (online) | |
| dc.identifier.issn | 0256-9574 (print) | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/7430 | |
| dc.language.iso | en | |
| dc.publisher | Health & Medical Publishing Group | |
| dc.rights.holder | South African Medical Journal | |
| dc.subject | Bone -- Diseases | en_ZA |
| dc.title | Influence of disodium etidronate on Paget's disease of bone | en_ZA |
| dc.type | Article |
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