Current use and acceptability of novel diagnostic tests for active tuberculosis : a worldwide survey

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dc.contributor.authorAmicosante, Massimoen_ZA
dc.contributor.authorD’Ambrosio, Liaen_ZA
dc.contributor.authorMunoz, Marcelaen_ZA
dc.contributor.authorMello, Fernanda Carvalho de Queirozen_ZA
dc.contributor.authorTebruegge, Marcen_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.contributor.authorSeghrouchni, Fouaden_ZA
dc.contributor.authorCentis, Rosellaen_ZA
dc.contributor.authorGoletti, Deliaen_ZA
dc.contributor.authorBothamley, Grahamen_ZA
dc.contributor.authorMigliori, Giovanni Battistaen_ZA
dc.contributor.authorTB Diagnostic Survey Working Groupen_ZA
dc.date.accessioned2019-01-28T13:46:09Z
dc.date.available2019-01-28T13:46:09Z
dc.date.issued2017-09-03
dc.descriptionCITATION: Amicosante, M., et al. 2017. Current use and acceptability of novel diagnostic tests for active tuberculosis : a worldwide survey. Jornal Brasileiro de Pneumologia, 43(5):380-392, doi:10.1590/S1806-37562017000000219.
dc.descriptionThe original publication is available at http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000500380&lng=en&tlng=en
dc.description.abstractObjective: To determine the current use and potential acceptance (by tuberculosis experts worldwide) of novel rapid tests for the diagnosis of tuberculosis that are in line with World Health Organization target product profiles. Methods: A multilingual survey was disseminated online between July and November of 2016. Results: A total of 723 individuals from 114 countries responded to the survey. Smear microscopy was the most commonly used rapid tuberculosis test (available to 90.9% of the respondents), followed by molecular assays (available to 70.7%). Only a small proportion of the respondents in middle- and low-income countries had access to interferon-gamma-release assays. Serological and lateral flow immunoassays were used by more than a quarter (25.4%) of the respondents. Among the respondents who had access to molecular tests, 46.7% were using the Xpert assay overall, that proportion being higher in lower middle-income countries (55.6%) and low-income countries (76.6%). The data also suggest that there was some alignment of pricing for molecular assays. Respondents stated they would accept novel rapid tuberculosis tests if available, including molecular assays (acceptable to 86.0%) or biomarker-based serological assays (acceptable to 81.7%). Simple biomarker-based assays were more commonly deemed acceptable in middle- and lowincome countries. Conclusions: Second-generation molecular assays have become more widely available in high- and low-resource settings. However, the development of novel rapid tuberculosis tests continues to be considered important by tuberculosis experts. Our data also underscore the need for additional training and education of end users.en_ZA
dc.description.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000500380
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationAmicosante, M., et al. 2017. Current use and acceptability of novel diagnostic tests for active tuberculosis : a worldwide survey. Jornal Brasileiro de Pneumologia, 43(5):380-392, doi:10.1590/S1806-37562017000000219
dc.identifier.issn1806-3756 (online)
dc.identifier.issn1806-3713 (print)
dc.identifier.otherdoi:10.1590/S1806-37562017000000219
dc.identifier.urihttp://hdl.handle.net/10019.1/105367
dc.language.isoen_ZAen_ZA
dc.publisherSociedade Brasileira de Pneumologia e Tisiologiaen_ZA
dc.rights.holderSociedade Brasileira de Pneumologia e Tisiologiaen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectTuberculosis -- Diagnosisen_ZA
dc.subjectMolecular diagnosis -- Methodologyen_ZA
dc.subjectSerodiagnosisen_ZA
dc.titleCurrent use and acceptability of novel diagnostic tests for active tuberculosis : a worldwide surveyen_ZA
dc.typeArticleen_ZA
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