Improved outcome in South African children of mixed ethnicity treated for all

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dc.contributor.authorDippenaar A.
dc.contributor.authorWessels G.
dc.contributor.authorHesseling P.B.
dc.date.accessioned2011-05-15T16:17:37Z
dc.date.available2011-05-15T16:17:37Z
dc.date.issued2006
dc.description.abstract□ A historical cohort study with an analytical component was conducted to determine whether risk-appropriate chemotherapy can improve survival in children of mixed ethnicity with ALL. Eighty-one coloured children treated for ALL in South Africa were divided into 2 groups: group A (n = 39), treated prior to 1992, and group B (n = 42), treated after 1992. A comparison was made of survival, treatment complications, and supportive measures. The two groups were comparable. The mean nadirs of the white cell count (p < .01), platelet count (p = .01), and hemoglobin value (p < .01) were significantly lower in group B. The survival rate of 37% in group A improved to 66% in group B (p = .025). The results show that a risk-adapted regimen increased survival in children of mixed ethnicity in the Western Cape, despite increased hematological toxicity and episodes of febrile neutropenia. Copyright © Taylor & Francis Group, LLC.
dc.description.versionArticle
dc.identifier.citationPediatric Hematology and Oncology
dc.identifier.citation23
dc.identifier.citation4
dc.identifier.issn08880018
dc.identifier.other10.1080/08880010600631979
dc.identifier.urihttp://hdl.handle.net/10019.1/14294
dc.subjectamikacin
dc.subjectantineoplastic agent
dc.subjectasparaginase
dc.subjectcyclophosphamide
dc.subjectcytarabine
dc.subjectdaunorubicin
dc.subjectdexamethasone
dc.subjectdoxorubicin
dc.subjectgranulocyte colony stimulating factor
dc.subjectmercaptopurine
dc.subjectmethotrexate
dc.subjectpiperacillin
dc.subjectprednisone
dc.subjecttioguanine
dc.subjectvancomycin
dc.subjectvincristine
dc.subjectarticle
dc.subjectblood transfusion
dc.subjectbone marrow toxicity
dc.subjectbrain radiation
dc.subjectcancer chemotherapy
dc.subjectcancer survival
dc.subjectchild
dc.subjectchildhood leukemia
dc.subjectclinical protocol
dc.subjecterythrocyte transfusion
dc.subjectethnic group
dc.subjectfebrile neutropenia
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectSouth Africa
dc.subjectthrombocyte transfusion
dc.subjecttreatment outcome
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subjectEthnic Groups
dc.subjectFemale
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectLeukemia, Lymphocytic, Acute, L1
dc.subjectLeukocyte Count
dc.subjectMale
dc.subjectNeutropenia
dc.subjectPlatelet Count
dc.subjectSouth Africa
dc.subjectSurvival Rate
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.titleImproved outcome in South African children of mixed ethnicity treated for all
dc.typeArticle
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