IMPUTOR : phylogenetically aware software for imputation of errors in next-generation sequencing

dc.contributor.authorJobin, Matthewen_ZA
dc.contributor.authorSchurz, Haikoen_ZA
dc.contributor.authorHenn, Brenna M.en_ZA
dc.date.accessioned2019-09-27T09:08:02Z
dc.date.available2019-09-27T09:08:02Z
dc.date.issued2018
dc.descriptionCITATION: Jobin, M., Schurz, H. & Henn, B. M. 2018. IMPUTOR : phylogenetically aware software for imputation of errors in next-generation sequencing. Genome Biology and Evolution, 10(5):1248-1254, doi:10.1093/gbe/evy088.
dc.descriptionThe original publication is available at https://academic.oup.com
dc.description.abstractENGLISH ABSTRACT: We introduce IMPUTOR, software for phylogenetically aware imputation of missing haploid nonrecombining genomic data. Targeted for next-generation sequencing data, IMPUTOR uses the principle of parsimony to impute data marked as missing due to low coverage.Alongwith efficiently imputingmissing variant genotypes, IMPUTOR is capable of reliably and accurately correcting manynonmissingsites that represent spurious sequencing errors. Testsonsimulateddata showthatIMPUTORis capable of detecting many induced mutations without making erroneous imputations/corrections, with as many as 95% of missing sites imputed and 81%of errors corrected under optimal conditions.We tested IMPUTOR with human Y-chromosomes from pairs of close relatives and demonstrate IMPUTOR’s efficacy in imputing missing and correcting erroneous calls.en_ZA
dc.description.urihttps://academic.oup.com/gbe/article/10/5/1248/4990909
dc.description.versionPublisher's version
dc.format.extent7 pagesen_ZA
dc.identifier.citationJobin, M., Schurz, H. & Henn, B. M. 2018. IMPUTOR : phylogenetically aware software for imputation of errors in next-generation sequencing. Genome Biology and Evolution, 10(5):1248-1254, doi:10.1093/gbe/evy088
dc.identifier.issn1759-6653 (online)
dc.identifier.otherdoi:10.1093/gbe/evy088
dc.identifier.urihttp://hdl.handle.net/10019.1/106532
dc.language.isoen_ZAen_ZA
dc.publisherOxford University Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTrees -- Phylogeny -- Molecular aspectsen_ZA
dc.subjectNext-generation sequencingen_ZA
dc.subjectGene banks (Genetic engineering)en_ZA
dc.titleIMPUTOR : phylogenetically aware software for imputation of errors in next-generation sequencingen_ZA
dc.typeArticleen_ZA
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