Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection

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dc.contributor.authorLakin, Hilary Annen_ZA
dc.contributor.authorTavalire, Hannahen_ZA
dc.contributor.authorSakamoto, Kaorien_ZA
dc.contributor.authorBuss, Peteren_ZA
dc.contributor.authorMiller, Micheleen_ZA
dc.contributor.authorBudischak, Sarah A.en_ZA
dc.contributor.authorRaum, Kristinaen_ZA
dc.contributor.authorEzenwa, Vanessa O.en_ZA
dc.contributor.authorBeechler, Briannaen_ZA
dc.contributor.authorJolles, Annaen_ZA
dc.date.accessioned2024-04-03T07:06:38Zen_ZA
dc.date.available2024-04-03T07:06:38Zen_ZA
dc.date.issued2022-11en_ZA
dc.descriptionThe original publication is available at: https://journals.plos.orgen_ZA
dc.descriptionCITATION: Lakin HA, et al. 2022 Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. PLoS Negl Trop Dis 16(11):13 pages. doi.10.1371/journal.pntd.0010906en_ZA
dc.description.abstractABSTRACT: Background Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions in controlled studies than murine models. If disease in African buffalo progresses similarly to experimentally infected cattle, they may serve as a model, both for human tuberculosis and cattle BTB, in a natural environment. Methodology/Principal findings We utilized a herd of African buffalo that were captured, fitted with radio collars, and tested for BTB twice annually during a 4-year-cohort study. At the end of the project, BTB positive buffalo were culled, and necropsies performed. Here we describe the pathologic progression of BTB over time in African buffalo, utilizing gross and histological methods. We found that BTB in buffalo follows a pattern of infection like that seen in experimental studies of cattle. BTB localizes to the lymph nodes of the respiratory tract first, beginning with the retropharyngeal and tracheobronchial lymph nodes, gradually increasing in lymph nodes affected over time. At 36 months, rate of spread to additional lymph nodes sharply increases. The lung lesions follow a similar pattern, progressing slowly, then accelerating their progression at 36 months post infection. Lastly, a genetic marker that correlated to risk of M. bovis infection in previous studies was marginally associated with BTB progression. Buffalo with at least one risk allele at this locus tended to progress faster, with more lung necrosis. Conclusions/Significance The progression of disease in the African buffalo mirrors the progression found in experimental cattle models, offering insight into BTB and the interaction with its host in the context of naturally varying environments, host, and pathogen populations.en_ZA
dc.description.urihttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010906en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent13 pages : illustrationsen_ZA
dc.identifier.citationLakin HA, et al. 2022 Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. PLoS Negl Trop Dis 16(11):13 pages. doi.10.1371/journal.pntd.0010906en_ZA
dc.identifier.doi10.1371/journal.pntd.0010906en_ZA
dc.identifier.issn1935-2727 (online)en_ZA
dc.identifier.orcid0000-0002-6126-1517en_ZA
dc.identifier.urihttps://scholar.sun.ac.za/handle/10019.1/129571en_ZA
dc.language.isoenen_ZA
dc.publisherPLOSen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subject.lcshTuberculosis in cattleen_ZA
dc.subject.lcshAfrican buffaloen_ZA
dc.subject.lcshZoonosesen_ZA
dc.subject.lcshUCTDen_ZA
dc.titleBovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infectionen_ZA
dc.typeArticleen_ZA
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