The challenge of chronic lung disease in HIV-infected children and adolescents

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dc.contributor.authorWeber, Heinrich C.en_ZA
dc.contributor.authorGie, Robert P.en_ZA
dc.contributor.authorCotton, Mark F.en_ZA
dc.date.accessioned2014-07-07T12:33:04Z
dc.date.available2014-07-07T12:33:04Z
dc.date.issued2013
dc.descriptionCITATION: Weber, H. C., Gie, R. P. & Cotton, M. F. 2013. The challenge of chronic lung disease in HIV-infected children and adolescents. Journal of the International AIDS Society, 16:18633, doi:10.7448/IAS.16.1.18633.
dc.descriptionThe original publication is available at https://onlinelibrary.wiley.com
dc.description.abstractUntil recently, little attention has been given to chronic lung disease (CLD) in HIV-infected children. As the HIV epidemic matures in sub-Saharan Africa, adolescents who acquired HIV by vertical transmission are presenting to health services with chronic diseases. The most common is CLD, which is often debilitating. This review summarizes the limited data available on the epidemiology, pathophysiology, clinical picture, special investigations and management of CLD in HIV-infected adolescents. A number of associated conditions: lymphocytic interstitial pneumonitis, tuberculosis and bronchiectasis are well described. Other pathologies such as HIV-associated bronchiolitis obliterans resulting in non-reversible airway obstruction, has only recently been described. In this field, there are many areas of uncertainty needing urgent research. These areas include the definition of CLD, pathophysiological mechanisms and common pathologies responsible. Very limited data are available to formulate an effective plan of investigation and management.
dc.description.versionPublisher's version
dc.format.extent6 pages
dc.identifier.citationWeber, H. C., Gie, R. P. & Cotton, M. F. 2013. The challenge of chronic lung disease in HIV-infected children and adolescents. Journal of the International AIDS Society, 16:18633, doi:10.7448/IAS.16.1.18633.
dc.identifier.issn1758-2652 (online)
dc.identifier.urihttp://hdl.handle.net/10019.1/94737
dc.language.isoen
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subject.otherRespiratory infections in childrenen_ZA
dc.titleThe challenge of chronic lung disease in HIV-infected children and adolescentsen_ZA
dc.typeArticle
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