Major flares in women with SLE on combined oral contraception

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dc.contributor.authorWhitelaw D.A.
dc.contributor.authorJessop S.J.
dc.date.accessioned2011-05-15T16:16:08Z
dc.date.available2011-05-15T16:16:08Z
dc.date.issued2007
dc.description.abstractTwo recent trials concluded that the use of oral contraceptives (OC) did not induce flares in lupus patients. We record our experience with OC in patients with stable lupus. Eight patients were enrolled in an open trial. Six received a combined contraceptive pill and two were allocated to the control arm. During a 12 month follow-up, 3 patients in the active arm experienced 4 major flares. One patient died as a result of uncontrolled disease complicated by sepsis. At this point, we abandoned the trial. The 2 patients in the control arm experienced no disease exacerbation during the 7 months of observation. We would urge that patients who are placed on OC be closely monitored. © Clinical Rheumatology 2007.
dc.description.versionArticle
dc.identifier.citationClinical Rheumatology
dc.identifier.citation26
dc.identifier.citation12
dc.identifier.issn07703198
dc.identifier.other10.1007/s10067-007-0641-y
dc.identifier.urihttp://hdl.handle.net/10019.1/13648
dc.subjectantibiotic agent
dc.subjectazathioprine
dc.subjectcreatine kinase
dc.subjectcyclophosphamide
dc.subjectestrogen
dc.subjectethinylestradiol plus levonorgestrel
dc.subjectmethotrexate
dc.subjectmethylprednisolone
dc.subjectoral contraceptive agent
dc.subjectprednisone
dc.subjectadult
dc.subjectarthritis
dc.subjectarticle
dc.subjectclinical feature
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectcreatine kinase blood level
dc.subjectdisease activity
dc.subjectdisease control
dc.subjectdisease severity
dc.subjectdrug pulse therapy
dc.subjectdrug response
dc.subjectdrug withdrawal
dc.subjectdyspnea
dc.subjectechocardiography
dc.subjectfatality
dc.subjectfemale
dc.subjectfever
dc.subjectfollow up
dc.subjecthuman
dc.subjectkidney biopsy
dc.subjectleukocytosis
dc.subjectlow drug dose
dc.subjectlung infiltrate
dc.subjectmyocarditis
dc.subjectmyositis
dc.subjectnephritis
dc.subjectopen study
dc.subjectoral contraception
dc.subjectpatient monitoring
dc.subjectpericardial effusion
dc.subjectpremenopause
dc.subjectpriority journal
dc.subjectrelapse
dc.subjectsepsis
dc.subjectsystemic lupus erythematosus
dc.subjectthorax pain
dc.subjecturine sediment
dc.subjectvasculitic rash
dc.subjectweakness
dc.subjectAdult
dc.subjectContraceptives, Oral
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHot Flashes
dc.subjectHumans
dc.subjectLupus Erythematosus, Systemic
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectRisk Factors
dc.titleMajor flares in women with SLE on combined oral contraception
dc.typeArticle
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