Risk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africa

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dc.contributor.authorShanaube, Kwameen_ZA
dc.contributor.authorHargreaves, Jamesen_ZA
dc.contributor.authorFielding, Katherineen_ZA
dc.contributor.authorSchaap, Aben_ZA
dc.contributor.authorLawrence, Katherine-Anneen_ZA
dc.contributor.authorHensen, Bernadetteen_ZA
dc.contributor.authorSismanidis, Charalambosen_ZA
dc.contributor.authorMenezes, Angelaen_ZA
dc.contributor.authorBeyers, Nuldaen_ZA
dc.contributor.authorAyles, Helenen_ZA
dc.contributor.authorGodfrey-Faussett, Peteren_ZA
dc.date.accessioned2011-05-15T16:00:14Z
dc.date.available2011-05-15T16:00:14Z
dc.date.issued2011-04
dc.descriptionThe original publication is available at http:/www.plosone.orgen_ZA
dc.description.abstractIntroduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection remains unclear in settings with a high burden of tuberculosis. Objectives: To determine risk factors associated with positive QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) results and the level of agreement between the tests; to explore the hypotheses that positivity in QFT-GIT is more related to recent infection and less affected by HIV than the TST. Methods: Adult household contacts of tuberculosis patients were invited to participate in a cross-sectional study across 24 communities in Zambia and South Africa. HIV, QFT-GIT and TST tests were done. A questionnaire was used to assess risk factors. Results: A total of 2,220 contacts were seen. 1,803 individuals had interpretable results for both tests, 1,147 (63.6%) were QFT-GIT positive while 725 (40.2%) were TST positive. Agreement between the tests was low (kappa = 0.24). QFT-GIT and TST results were associated with increasing age (adjusted OR [aOR] for each 10 year increase for QFT-GIT 1.15; 95% CI: 1.06-1.25, and for TST aOR: 1.10; 95% CI 1.01-1.20). HIV positivity was less common among those with positive results on QFT-GIT (aOR: 0.51; 95% CI: 0.39-0.67) and TST (aOR: 0.61; 95% CI: 0.46-0.82). Smear positivity of the index case was associated with QFT-GIT (aOR: 1.25; 95% CI: 0.90-1.74) and TST (aOR: 1.39; 95% CI: 0.98-1.98) results. We found little evidence in our data to support our hypotheses. Conclusion: QFT-GIT may not be more sensitive than the TST to detect risk factors associated with tuberculous infection. We found little evidence to support the hypotheses that positivity in QFT-GIT is more related to recent infection and less affected by HIV than the TST. © 2011 Shanaube et al.en_ZA
dc.description.versionPublishers' Versionen_ZA
dc.format.extent11 p. : ill.
dc.identifier.citationShanaube, K, et al. 2011. Risk Factors Associated with Positive QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests Results in Zambia and South Africa. PLoS ONE, 6(4): e18206, doi:10.1371/journal.pone.0018206.en_ZA
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0018206
dc.identifier.urihttp://hdl.handle.net/10019.1/11596
dc.language.isoen_ZA
dc.publisherPublic Library of Science (PLOS)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectSouth Africa -- Medical policyen_ZA
dc.subjectZambia -- Medical policyen_ZA
dc.subjectQuantiFERON-TB Gold In-Tube (QFT-GIT) -- Therapeutic useen_ZA
dc.subjectTuberculosis -- Diagnosis -- Zambiaen_ZA
dc.subjectTuberculin skin test -- Therapeutic useen_ZA
dc.subjectTuberculosis -- Diagnosis -- South Africaen_ZA
dc.subjectTuberculin skin tests -- Risk factorsen_ZA
dc.subjectTuberculous infections -- Vaccinationen_ZA
dc.subject.lcshTuberculosis -- Risk factorsen_ZA
dc.titleRisk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africaen_ZA
dc.typeArticleen_ZA
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