MRI to demonstrate diagnostic features and complications of TBM not seen with CT

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dc.contributor.authorPienaar M.
dc.contributor.authorAndronikou S.
dc.contributor.authorVan Toorn R.
dc.date.accessioned2011-05-15T16:16:02Z
dc.date.available2011-05-15T16:16:02Z
dc.date.issued2009
dc.description.abstractBackground: Computed tomography (CT) findings in children with tuberculous meningitis (TBM) often do not explain the clinical presentation and may even be normal. Magnetic resonance imaging (MRI) has the potential to diagnose TBM with greater sensitivity than CT and also to detect more infarcts. Aim: The aim of this study was to determine whether MRI demonstrates features and complications of TBM not present on CT. Materials and methods: Retrospective, blinded evaluation and comparison of CT and MRI findings in children with TBM were performed. Results: Of 30 children included, MRI demonstrated eight more with basal enhancement and four more with infarctions. Overall, MRI demonstrated an additional 104 sites of infarction (of a total 172) than CT. Of these, 89 were acute and visualized only on diffusion-weighted image. MRI showed five more patients with unilateral and two more with bilateral basal ganglia infarcts than CT as well as 19 brainstem infarcts. Hydrocephalus was equally detected by MRI and CT. Conclusion: MRI is superior to CT for diagnosing TBM (by detecting basal enhancement in more patients) and prognosis (by detecting many more infarcts in strategic locations). The role of CT is defined for the acute setting in detecting hydrocephalus for surgical management. © 2008 Springer-Verlag.
dc.description.versionArticle
dc.identifier.citationChild's Nervous System
dc.identifier.citation25
dc.identifier.citation8
dc.identifier.issn02567040
dc.identifier.other10.1007/s00381-008-0785-3
dc.identifier.urihttp://hdl.handle.net/10019.1/13601
dc.subjectadolescent
dc.subjectarticle
dc.subjectbasal ganglia infarction
dc.subjectbilateral thalami infarction
dc.subjectbrain infarction
dc.subjectbrain stem infarction
dc.subjectcerebellum infarction
dc.subjectchild
dc.subjectclinical article
dc.subjectcomputer assisted tomography
dc.subjectcorpus callosum infarction
dc.subjectdiffusion weighted imaging
dc.subjectextrapyramidal syndrome
dc.subjectfemale
dc.subjecthuman
dc.subjecthydrocephalus
dc.subjectinfant
dc.subjectmale
dc.subjectnuclear magnetic resonance imaging
dc.subjectpreschool child
dc.subjectpriority journal
dc.subjectschool child
dc.subjectthalamic infarction
dc.subjecttuberculous meningitis
dc.subjectAdolescent
dc.subjectBrain
dc.subjectBrain Infarction
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectGranuloma
dc.subjectHumans
dc.subjectHydrocephalus
dc.subjectInfant
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectTomography, X-Ray Computed
dc.subjectTuberculosis, Meningeal
dc.titleMRI to demonstrate diagnostic features and complications of TBM not seen with CT
dc.typeArticle
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