Effect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in research collaboration

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dc.contributor.authorNachega, Jean Ben_ZA
dc.contributor.authorSam-Agudu, Nadia Aen_ZA
dc.contributor.authorBudhram, Samanthaen_ZA
dc.date.accessioned2022-04-23T13:38:47Z
dc.date.available2022-04-23T13:38:47Z
dc.date.issued2020-12
dc.description.abstractIn the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research is critically needed to evaluate the effects of the added burden of COVID-19 in pregnancy, to help develop evidence-based policies toward improving maternal and infant outcomes. In this perspective, we briefly review current knowledge on the clinical features of COVID-19 in pregnancy; the risks of preterm birth and cesarean delivery secondary to comorbid severity; the effects of maternal SARS-CoV-2 infection on the fetus/neonate; and in utero mother-to-child SARS-CoV-2 transmission. We further highlight the need to conduct multicountry surveillance as well as retrospective and prospective cohort studies across SSA. This will enable assessments of SARS-CoV-2 burden among pregnant African women and improve the understanding of the spectrum of COVID-19 manifestations in this population, which may be living with or without HIV, TB, and/or other coinfections/comorbidities. In addition, multicountry studies will allow a better understanding of risk factors and outcomes to be compared across countries and subregions. Such an approach will encourage and strengthen much-needed intra-African, south-to-south multidisciplinary and interprofessional research collaborations. The African Forum for Research and Education in Health’s COVID-19 Research Working Group has embarked upon such a collaboration across Western, Central, Eastern and Southern Africa.en_ZA
dc.format5 pages
dc.identifier.otherdoi:10.4269/ajtmh.20-1553
dc.identifier.urihttp://hdl.handle.net/10019.1/124466
dc.language.isoen_ZAen_ZA
dc.rights.holderAuthors retain copyright
dc.subjectEffecten_ZA
dc.subjectSARS-CoV-2en_ZA
dc.subjectPregnancyen_ZA
dc.subjectMaternal and Neonatalen_ZA
dc.subjectAfricaen_ZA
dc.titleEffect of SARS-CoV-2 infection in pregnancy on maternal and neonatal outcomes in research collaborationen_ZA
dc.typeArticleen_ZA
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