Hearing loss in patients on treatment for drug-resistant tuberculosis

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dc.contributor.authorSeddon, James A.
dc.contributor.authorGodfrey-Faussett, Peter
dc.contributor.authorJacobs, Kayleen
dc.contributor.authorEbrahim, Adam
dc.contributor.authorHesseling, Anneke C.
dc.contributor.authorSchaaf, H. Simon
dc.date.accessioned2012-06-15T12:22:46Z
dc.date.available2012-06-15T12:22:46Z
dc.date.issued2012-06
dc.descriptionThe original publication is available at http://erj.ersjournals.com/en_ZA
dc.descriptionPublished ahead of print on 14 June 2012, as a manuscript, for the June publication. Indicated on the Website as ERJ in press the copyediting, typesetting, and proofreading, has not been performed.en_ZA
dc.descriptionBibliography
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.
dc.description.abstractThe treatment of drug‐resistant (DR) tuberculosis (TB) necessitates the use of second‐line injectable anti‐TB drugs which are associated with hearing loss. Hearing loss affects communication and for children the development of language and social skills. This article describes the pathophysiology of hearing loss and the testing methodologies that can be employed. It is the first paper to systematically review the literature regarding hearing loss in those treated for DR‐TB. In the studies identified, the methodology used to test for and to classify hearing loss is inconsistent and children and those with HIV are poorly represented. The review describes existing guidelines and suggests management strategies when hearing loss is found. It describes the challenges of testing hearing in the developing world contexts where the majority of patients with DR‐TB are treated. Finally it makes the recommendation that a standardised testing methodology and classification system be used.en_ZA
dc.description.versionPost-printen_ZA
dc.format.extent22 p. : ill.
dc.identifier.citationSeddon, J. A. et al. 2012. Hearing loss in patients on treatment for drug-resistant tuberculosis.. European Respiratory Journal, doi:10.1183/09031936.00044812.en_ZA
dc.identifier.otherdoi:10.1183/09031936.00044812
dc.identifier.urihttp://hdl.handle.net/10019.1/21424
dc.language.isoen_ZAen_ZA
dc.publisherEuropean Respiratory Societyen_ZA
dc.rights.holderAuthors retain the copyrighten_ZA
dc.subjectHearing loss -- Effect of drug resistant tuberculosis onen_ZA
dc.subjectDrug‐resistant tuberculosisen_ZA
dc.subjectOtotoxicityen_ZA
dc.titleHearing loss in patients on treatment for drug-resistant tuberculosisen_ZA
dc.typeArticleen_ZA
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