Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa
| dc.contributor.author | Kastien-Hilka, Tanja | en_ZA |
| dc.contributor.author | Rosenkranz, Bernd | en_ZA |
| dc.contributor.author | Schwenkglenks, Matthias | en_ZA |
| dc.contributor.author | Bennett, Bryan M. | en_ZA |
| dc.contributor.author | Sinanovic, Edina | en_ZA |
| dc.date.accessioned | 2019-02-04T09:52:08Z | |
| dc.date.available | 2019-02-04T09:52:08Z | |
| dc.date.issued | 2017-12-18 | |
| dc.description | CITATION: Kastien-Hilka, T., et al. 2017. Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa. Frontiers in Pharmacology, 8:919, doi:10.3389/fphar.2017.00919. | |
| dc.description | The original publication is available at https://www.frontiersin.org | |
| dc.description.abstract | Background: Health-related quality of life (HRQOL) and adherence to treatment are two often inter-related concepts that have implications for patient management and care. Tuberculosis (TB) and its treatment present a major public health concern in South Africa. The study aimed to evaluate the association between HRQOL and adherence in TB patients in South Africa. Methods: Four self-reported HRQOL and one self-reported adherence measures were used in an observational longitudinal multicentre study during 6-month standard TB treatment. These included the generic Short-Form 12 items (SF-12) and European Quality of Life 5 dimensions 5 levels (EQ-5D-5L), the disease-specific St. George's Respiratory Questionnaire (SGRQ) and the condition-specific Hospital Anxiety and Depression Scale (HADS) for HRQOL. Adherence was measured by the Morisky Medication Adherence Scale 8 items (MMAS-8). The relationship between both concepts was examined in 131 patients using Spearman's rho correlations, and linear regression models. Results: HRQOL improved over 6-month TB treatment, whereas adherence mean scores stayed constant with participants attaining a medium average level. Around 76% of patients reported to be high adherers and 24% were reporting a medium or low adherence. Associations between HRQOL and adherence were mainly weak. High adherence at treatment start was positively related to improvements in anxiety and depression after 6-month treatment. The overall improvement in pain and discomfort, and psychosocial health aspects over treatment time was positively, but weakly associated with adherence at 6 months of treatment. Conclusion: A positive relationship exists between adherence and HRQOL in TB in a South African setting, but this relationship was very weak, most likely because HRQOL is affected by a number of different factors and not limited to effects of adherence. Therefore, management of TB patients should, besides adequate drug treatment, address the specific mental and psychosocial needs. | en_ZA |
| dc.description.uri | https://www.frontiersin.org/articles/10.3389/fphar.2017.00919/full | |
| dc.description.version | Publisher's version | |
| dc.format.extent | 7 pages | en_ZA |
| dc.identifier.citation | Kastien-Hilka, T., et al. 2017. Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa. Frontiers in Pharmacology, 8:919, doi:10.3389/fphar.2017.00919 | |
| dc.identifier.issn | 1663-9812 (online) | |
| dc.identifier.other | doi:10.3389/fphar.2017.00919 | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/105380 | |
| dc.language.iso | en_ZA | en_ZA |
| dc.publisher | Frontiers Media | en_ZA |
| dc.rights.holder | Authors retain copyright | en_ZA |
| dc.subject | Pulmonary tuberculosis | en_ZA |
| dc.subject | Treatment compliance | en_ZA |
| dc.subject | Tuberculosis patients -- Quality of life | en_ZA |
| dc.title | Association between health-related quality of life and medication adherence in pulmonary tuberculosis in South Africa | en_ZA |
| dc.type | Article | en_ZA |