Early-life gut dysbiosis linked to juvenile mortality in ostriches

Simple item page
dc.contributor.authorVidevall, Elinen_ZA
dc.contributor.authorSong, Se Jinen_ZA
dc.contributor.authorBensch, Hanna M.en_ZA
dc.contributor.authorStrandh, Mariaen_ZA
dc.contributor.authorEngelbrecht, Anelen_ZA
dc.contributor.authorSerfontein, Naomien_ZA
dc.contributor.authorHellgren, Olofen_ZA
dc.contributor.authorOlivier, Adriaanen_ZA
dc.contributor.authorCloete, Schalken_ZA
dc.contributor.authorKnight, Roben_ZA
dc.contributor.authorCornwallis, Charlie K.en_ZA
dc.date.accessioned2021-04-29T10:22:33Z
dc.date.available2021-04-29T10:22:33Z
dc.date.issued2020-10-12
dc.date.updated2020-10-18T04:20:46Z
dc.descriptionCITATION: Videvall, E., et al. 2020. Early-life gut dysbiosis linked to juvenile mortality in ostriches. Microbiome, 8:147, doi:10.1186/s40168-020-00925-7.
dc.descriptionThe original publication is available at https://microbiomejournal.biomedcentral.com
dc.description.abstractBackground: Imbalances in the gut microbial community (dysbiosis) of vertebrates have been associated with several gastrointestinal and autoimmune diseases. However, it is unclear which taxa are associated with gut dysbiosis, and if particular gut regions or specific time periods during ontogeny are more susceptible. We also know very little of this process in non-model organisms, despite an increasing realization of the general importance of gut microbiota for health. Methods: Here, we examine the changes that occur in the microbiome during dysbiosis in different parts of the gastrointestinal tract in a long-lived bird with high juvenile mortality, the ostrich (Struthio camelus). We evaluated the 16S rRNA gene composition of the ileum, cecum, and colon of 68 individuals that died of suspected enterocolitis during the first 3 months of life (diseased individuals), and of 50 healthy individuals that were euthanized as age-matched controls. We combined these data with longitudinal environmental and fecal sampling to identify potential sources of pathogenic bacteria and to unravel at which stage of development dysbiosisassociated bacteria emerge. Results: Diseased individuals had drastically lower microbial alpha diversity and differed substantially in their microbial beta diversity from control individuals in all three regions of the gastrointestinal tract. The clear relationship between low diversity and disease was consistent across all ages in the ileum, but decreased with age in the cecum and colon. Several taxa were associated with mortality (Enterobacteriaceae, Peptostreptococcaceae, Porphyromonadaceae, Clostridium), while others were associated with health (Lachnospiraceae, Ruminococcaceae, Erysipelotrichaceae, Turicibacter, Roseburia). Environmental samples showed no evidence of dysbiosis-associated bacteria being present in either the food, water, or soil substrate. Instead, the repeated fecal sampling showed that pathobionts were already present shortly after hatching and proliferated in individuals with low microbial diversity, resulting in high mortality several weeks later. Conclusions: Identifying the origins of pathobionts in neonates and the factors that subsequently influence the establishment of diverse gut microbiota may be key to understanding dysbiosis and host development.
dc.description.urihttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00925-7
dc.description.versionPublisher's version
dc.format.extent13 pages : illustrations (some color)en_ZA
dc.identifier.citationVidevall, E., et al. 2020. Early-life gut dysbiosis linked to juvenile mortality in ostriches. Microbiome, 8:147, doi:10.1186/s40168-020-00925-7
dc.identifier.issn2049-2618 (online)
dc.identifier.otherdoi:10.1186/s40168-020-00925-7
dc.identifier.urihttp://hdl.handle.net/10019.1/110374
dc.languageen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectDysbacteriosis
dc.subjectMicrobial diversityen_ZA
dc.subjectOstrichesen_ZA
dc.subjectOstriches -- Bacterial diseasesen_ZA
dc.titleEarly-life gut dysbiosis linked to juvenile mortality in ostrichesen_ZA
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
videvall_earlylife_2020.pdf
Size:
3.36 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Animal Sciences)