The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional study

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dc.contributor.authorGeorge, Cindyen_ZA
dc.contributor.authorMatsha, Tandi E.en_ZA
dc.contributor.authorKorf, Mariznaen_ZA
dc.contributor.authorZemlin, Annalise E.en_ZA
dc.contributor.authorErasmus, Rajiv T.en_ZA
dc.contributor.authorKengne, Andre P.en_ZA
dc.date.accessioned2020-02-03T06:29:15Z
dc.date.available2020-02-03T06:29:15Z
dc.date.issued2020-01-30
dc.date.updated2020-02-02T04:20:42Z
dc.descriptionCITATION: George, C., et al. 2020. The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional study. BMC Nephrology, 21:32, doi:10.1186/s12882-020-1697-z.
dc.descriptionThe original publication is available at https://bmcnephrol.biomedcentral.com
dc.description.abstractBackground: To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans. Methods: CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2. Fasting plasma glucose and haemoglobin A1c (HbA1c) concentrations were measured by enzymatic hexokinase method and highperformance liquid chromatography, respectively, with fructosamine and glycated albumin measured by immunoturbidimetry and enzymatic method, respectively. Results: Of those with CKD (n = 96), 79, 16 and 5% where in stages 3, 4 and 5, respectively. Those with CKD had higher levels of HbA1c (6.2 vs. 5.7%; p < 0.0001), glycated albumin (15.0 vs. 13.0%; p < 0.0001) and fructosamine levels (269.7 vs. 236.4 μmol/l; p < 0.0001), compared to those without CKD. Higher fasting glucose levels were associated with higher HbA1c, glycated albumin and fructosamine, independent of age, gender, and CKD. However, the association with HbA1c and glycated albumin differed by CKD status, at the upper concentrations of the respective markers (interaction term for both: p ≤ 0.095). Conclusion: Our results suggest that although HbA1c and glycated albumin perform acceptably under conditions of normoglycaemia, these markers correlate less well with blood glucose levels in people with CKD who are not on dialysis.
dc.description.urihttps://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-1697-z
dc.description.versionPublisher's version
dc.format.extent11 pagesen_ ZA
dc.identifier.citationGeorge, C., et al. 2020. The agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional study. BMC Nephrology, 21:32, doi:10.1186/s12882-020-1697-z
dc.identifier.issn1471-2369 (online)
dc.identifier.otherdoi:10.1186/s12882-020-1697-z
dc.identifier.urihttp://hdl.handle.net/10019.1/107412
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectChronic kidney diseaseen_ZA
dc.subjectGlycaemic — Chronic diseasesen_ ZA
dc.subjectGlucose — Fastingen_ZA
dc.titleThe agreement between fasting glucose and markers of chronic glycaemic exposure in individuals with and without chronic kidney disease : a cross-sectional studyen_ ZA
dc.typeArticleen_ ZA
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