Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry : baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study

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dc.contributor.authorFourie, Carla M. T.en_ZA
dc.contributor.authorBotha-Le Roux, Shanien_ZA
dc.contributor.authorSmith, Wayneen_ZA
dc.contributor.authorSchutte, Aletta E.en_ZA
dc.contributor.authorBreet, Yolandien_ZA
dc.contributor.authorMels, Carina M. C.en_ZA
dc.contributor.authorGafane-Matemane, Lebo F.en_ZA
dc.contributor.authorLammertyn, Leandien_ZA
dc.contributor.authorUys, Lisaen_ZA
dc.contributor.authorBurger, Adeleen_ZA
dc.contributor.authorJoseph, Jitcy S.en_ZA
dc.contributor.authorGoswami, Nanduen_ZA
dc.contributor.authorDe Boever, Patricken_ZA
dc.contributor.authorStrijdom, Hansen_ZA
dc.date.accessioned2020-07-27T07:08:39Z
dc.date.available2020-07-27T07:08:39Z
dc.date.issued2020-07-03
dc.date.updated2020-07-05T04:00:25Z
dc.descriptionCITATION: Fourie, C. M. T., et al. 2020. Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry : baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study. BMC Infectious Diseases, 20:473, di:10.1186/s12879-020-05173-6.
dc.descriptionThe original publication is available at https://bmcinfectdis.biomedcentral.com
dc.description.abstractBackground: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection with HIV contributes to the development of CVD independent of traditional risk factors, with endothelial dysfunction being the central physiological mechanism. While HIV-related mortality is declining due to antiretroviral treatment (ART), the number of deaths due to CVD is rising in South Africa - the country with the highest number of PLHIV and the world’s largest ART programme. The EndoAfrica study was developed to determine whether HIV infection and ART are associated with cardiovascular risk markers and changes in vascular structure and function over 18months in adults from different provinces of South Africa. This paper describes the rationale, methodology and baseline cohort profile of the EndoAfrica study conducted in the North West Province, South Africa. Methods: In this case-control study, conducted between August 2017 and June 2018, 382 volunteers of African descent (276 women; 106 men), comprising of 278 HIV infected and 104 HIV free individuals were included. We measured health behaviours, a detailed cardiovascular profile, and performed biomarker analyses. We compared baseline characteristics, blood pressure, vascular function and biochemical markers between those infected and HIV free. Results: At baseline, the HIV infected participants were older (43 vs 39 years), less were employed (21% vs 40%), less had a tertiary education (7% vs 16%) and their body mass index was lower (26 vs 29 kg/m2) than that of the HIV free participants. While the cardiovascular profile, flow-mediated dilation and pulse wave velocity did not differ, glycated haemoglobin was lower (p = 0.017) and total cholesterol, high density lipoprotein cholesterol, triglycerides, gammaglutamyltransferase and tobacco use were higher (all p < 0.047) in PLHIV. Conclusion: Despite PLHIV being older, preliminary cross-sectional analysis suggests that PLHIV being treated with ART do not have poorer endothelial or vascular function compared to the HIV free participants. More detailed analyses on the baseline and follow-up data will provide further clarity regarding the cardiovascular profile of South Africans living with HIV.
dc.description.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05173-6
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationFourie, C. M. T., et al. 2020. Vascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry : baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU study. BMC Infectious Diseases, 20:473, di:10.1186/s12879-020-05173-6
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdi:10.1186/s12879-020-05173-6
dc.identifier.urihttp://hdl.handle.net/10019.1/108737
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAntiretroviral therapyen_ZA
dc.subjectCardiovascular disease -- Risk Managementen_ZA
dc.subjectHIV-infected personsen_ZA
dc.subjectAfrica -- Ancestryen_ZA
dc.titleVascular function and cardiovascular risk in a HIV infected and HIV free cohort of African ancestry : baseline profile, rationale and methods of the longitudinal EndoAfrica-NWU studyen_ZA
dc.typeArticleen_ZA
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