Pregnancy in systemic lupus erythematosus: A retrospective study from a developing community

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dc.contributor.authorWhitelaw D.A.
dc.contributor.authorHall D.
dc.contributor.authorKotze T.
dc.date.accessioned2011-05-15T16:16:08Z
dc.date.available2011-05-15T16:16:08Z
dc.date.issued2008
dc.description.abstractLittle data exists from the developing world on pregnancy in systemic lupus erythematosus (SLE). A 10-year review of pregnancies in lupus patients was conducted at a tertiary hospital in a developing country. Forty-seven pregnancies in 31 patients were identified. Eleven (23%) booked after 20 weeks gestation. There were no maternal deaths; six (13%) mothers experienced flares - all mild. Twelve women developed preeclampsia of which one experienced an intrauterine death. One patient was diagnosed with lupus and nephritis during pregnancy. She required an abortion to control the disease. Another with active nephritis delivered a normal but premature infant despite cyclophosphamide therapy. There was only minor deterioration in renal function. There were 36 (77%) live births, 8 first trimester abortions, 2 elective abortions and 1 still birth. Fourteen (39%) of live births were premature, and five (14%) experienced intrauterine growth retardation (IUGR). Two live-born babies experienced neonatal heartblock, and one, a neonatal lupus rash. We discuss these finding in relation to risk factors and to results from the developed world. © Clinical Rheumatology 2007.
dc.description.versionArticle
dc.identifier.citationClinical Rheumatology
dc.identifier.citation27
dc.identifier.citation5
dc.identifier.issn07703198
dc.identifier.other10.1007/s10067-007-0749-0
dc.identifier.urihttp://hdl.handle.net/10019.1/13647
dc.subjectcyclophosphamide
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcongenital heart block
dc.subjectdeveloping country
dc.subjectdisease exacerbation
dc.subjectfemale
dc.subjectfetus death
dc.subjectfetus outcome
dc.subjecthuman
dc.subjectintrauterine growth retardation
dc.subjectkidney dysfunction
dc.subjectlupus erythematosus nephritis
dc.subjectpreeclampsia
dc.subjectpregnancy outcome
dc.subjectpregnancy termination
dc.subjectprematurity
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectspontaneous abortion
dc.subjectsystemic lupus erythematosus
dc.subjectsystemic lupus erythematosus rash
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntibodies, Antiphospholipid
dc.subjectComplement System Proteins
dc.subjectDeveloping Countries
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant, Low Birth Weight
dc.subjectInfant, Newborn
dc.subjectInfant, Premature
dc.subjectLupus Erythematosus, Systemic
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectPregnancy Outcome
dc.subjectRaynaud Disease
dc.subjectRetrospective Studies
dc.subjectSouth Africa
dc.titlePregnancy in systemic lupus erythematosus: A retrospective study from a developing community
dc.typeArticle
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