Application of finite element analysis to the design of tissue leaflets for a percutaneous aortic valve

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dc.contributor.authorSmuts A.N.
dc.contributor.authorBlaine D.C.
dc.contributor.authorScheffer C.
dc.contributor.authorWeich H.
dc.contributor.authorDoubell A.F.
dc.contributor.authorDellimore K.H.
dc.date.accessioned2011-05-15T16:17:10Z
dc.date.available2011-05-15T16:17:10Z
dc.date.issued2011
dc.description.abstractPercutaneous Aortic Valve (PAV) replacement is an attractive alternative to open heart surgery, especially for patients considered to be poor surgical candidates. Despite this, PAV replacement still has its limitations and associated risks. Bioprosthetic heart valves still have poor long-term durability due to calcification and mechanical failure. In addition, the implantation procedure often presents novel challenges, including damage to the expandable stents and bioprosthetic leaflets. In this study, a simplified version of Fung's elastic constitutive model for skin, developed by Sun and Sacks, was implemented using finite element analysis (FEA) and applied to the modelling of bovine and kangaroo pericardium. The FEA implementation was validated by simulating biaxial tests and by comparing the results with experimental data. Concepts for different PAV geometries were developed by incorporating valve design and performance parameters, along with stent constraints. The influence of effects such as different leaflet material, material orientation and abnormal valve dilation on the valve function was investigated. The stress distribution across the valve leaflet was also examined to determine the appropriate fibre direction for the leaflet. The simulated attachment forces were compared with suture tearing tests performed on the pericardium to evaluate suture density. It is concluded that kangaroo pericardium is suitable for PAV applications, and superior to bovine pericardium, due to its lower thickness and greater extensibility. © 2010 Elsevier Ltd.
dc.description.versionArticle
dc.identifier.citationJournal of the Mechanical Behavior of Biomedical Materials
dc.identifier.citation4
dc.identifier.citation1
dc.identifier.issn17516161
dc.identifier.other10.1016/j.jmbbm.2010.09.009
dc.identifier.urihttp://hdl.handle.net/10019.1/14100
dc.subjectAortic valve leaflets
dc.subjectAortic valves
dc.subjectBiaxial tissue testing
dc.subjectBovine pericardium
dc.subjectFinite element analysis
dc.subjectKangaroo pericardium
dc.subjectBiomineralization
dc.subjectBlood vessels
dc.subjectConstitutive models
dc.subjectStress concentration
dc.subjectTissue
dc.subjectTransplantation (surgical)
dc.subjectValves (mechanical)
dc.subjectFinite element method
dc.subjectcollagen
dc.subjectglutaraldehyde
dc.subjectaorta
dc.subjectarticle
dc.subjectcow
dc.subjectfinite element analysis
dc.subjectforce
dc.subjectgeometry
dc.subjectheart valve
dc.subjectkangaroo
dc.subjectpericardium
dc.subjectpriority journal
dc.subjectsimulation
dc.subjectAnimals
dc.subjectAortic Valve
dc.subjectAortic Valve Stenosis
dc.subjectBiomechanics
dc.subjectBiomedical Engineering
dc.subjectBioprosthesis
dc.subjectCattle
dc.subjectElastic Modulus
dc.subjectFinite Element Analysis
dc.subjectHeart Valve Prosthesis
dc.subjectHeart Valve Prosthesis Implantation
dc.subjectHumans
dc.subjectMacropodidae
dc.subjectMaterials Testing
dc.subjectModels, Cardiovascular
dc.subjectNonlinear Dynamics
dc.subjectPericardium
dc.subjectProsthesis Design
dc.subjectStress, Mechanical
dc.subjectSuture Techniques
dc.subjectTissue Engineering
dc.titleApplication of finite element analysis to the design of tissue leaflets for a percutaneous aortic valve
dc.typeArticle
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