Bimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africa

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dc.contributor.authorDowns, Louise O.en_ZA
dc.contributor.authorVawda, Sabeehahen_ZA
dc.contributor.authorBester, Phillip Armanden_ZA
dc.contributor.authorLythgoe, Katrina A.en_ZA
dc.contributor.authorWang, Tingyanen_ZA
dc.contributor.authorMcNaughton, Anna L.en_ZA
dc.contributor.authorSmith, David A.en_ZA
dc.contributor.authorMaponga, Tongaien_ZA
dc.contributor.authorFreeman, Oliveren_ZA
dc.contributor.authorVárnai, Kinga A.en_ZA
dc.contributor.authorDavies, Jimen_ZA
dc.contributor.authorWoods, Kerrieen_ZA
dc.contributor.authorFraser, Christopheen_ZA
dc.contributor.authorBarnes, Eleanoren_ZA
dc.contributor.authorGoedhals, Dominiqueen_ZA
dc.contributor.authorMatthews, Philippa C.en_ZA
dc.date.accessioned2022-04-13T06:52:42Z
dc.date.available2022-04-13T06:52:42Z
dc.date.issued2020-10-14
dc.descriptionCITATION: Downs, L. O. 2020. Bimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africa. Wellcome Open Research, 14(5):113, doi: 10.12688/wellcomeopenres.15941.2.en_ZA
dc.descriptionThe original publication is available at: https://pubmed.ncbi.nlm.nih.gov
dc.description.abstractENGLISH ABSTRACT: Hepatitis B virus (HBV) viral load (VL) is used as a biomarker to assess risk of disease progression, and to determine eligibility for treatment. While there is a well recognised association between VL and the expression of the viral e-antigen protein, the distributions of VL at a population level are not well described. We here present cross-sectional, observational HBV VL data from two large population cohorts in the UK and in South Africa, demonstrating a consistent bimodal distribution. The right skewed distribution and low median viral loads are different from the left-skew and higher viraemia in seen in HIV and hepatitis C virus (HCV) cohorts in the same settings. Using longitudinal data, we present evidence for a stable 'set-point' VL in peripheral blood during chronic HBV infection. These results are important to underpin improved understanding of HBV biology, to inform approaches to viral sequencing, and to plan public health interventions.en_ZA
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationDowns, L. O. 2020. Bimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africa. Wellcome Open Research, 14(5):113, doi: 10.12688/wellcomeopenres.15941.2
dc.identifier.otherdoi: 10.12688/wellcomeopenres.15941.2
dc.identifier.urihttp://hdl.handle.net/10019.1/124453
dc.language.isoen_ZAen_ZA
dc.publisherWellcome Open Researchen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHepatitis B virusen_ZA
dc.subjectHIV infectionsen_ZA
dc.subjectViral loaden_ZA
dc.subjectHIV infections -- Treatmenten_ZA
dc.titleBimodal distribution and set point HBV DNA viral loads in chronic infection : retrospective analysis of cohorts from the UK and South Africaen_ZA
dc.typeArticleen_ZA
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