The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

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dc.contributor.authorWomersley, Jacqueline S.en_ZA
dc.contributor.authorClauss, Lara B.en_ZA
dc.contributor.authorVarathan, Olivetteen_ZA
dc.contributor.authorEngelbrecht, Susanen_ZA
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorSpies, Georginaen_ZA
dc.date.accessioned2020-01-15T06:27:53Z
dc.date.available2020-01-15T06:27:53Z
dc.date.issued2019-12-27
dc.date.updated2019-12-29T04:12:34Z
dc.descriptionCITATION: Womersley, J. S., et al. 2019. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes, 12:828, doi:10.1186/s13104-019-4869-9.
dc.descriptionThe original publication is available at https://bmcresnotes.biomedcentral.com
dc.description.abstractObjective: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. Results: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).en
dc.description.urihttps://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4869-9
dc.description.versionPublisher's version
dc.format.extent7 pages ; illustrations
dc.identifier.citationWomersley, J. S., et al. 2019. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes, 12:828, doi:10.1186/s13104-019-4869-9
dc.identifier.issn1756-0500 (online)
dc.identifier.otherdoi:10.1186/s13104-019-4869-9
dc.identifier.urihttp://hdl.handle.net/10019.1/107352
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectApolipoprotein E
dc.subjectEarly life traumaen_ZA
dc.subjectViral protein Ren_ZA
dc.subjectCognitive performanceen_ZA
dc.titleThe effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performanceen_ZA
dc.typeArticleen_ZA
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