Adipose tissue as a possible therapeutic target for polyphenols : a case for Cyclopia extracts as anti-obesity nutraceuticals

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dc.contributor.authorJack, Babalwa U.en_ZA
dc.contributor.authorMalherbe, Christiaan J.en_ZA
dc.contributor.authorMamushi, Mokadi Peggyen_ZA
dc.contributor.authorMuller, Christo J. F.en_ZA
dc.contributor.authorJoubert, Elizabethen_ZA
dc.contributor.authorLouwa, Johanen_ZA
dc.contributor.authorPheiffer, Carmenen_ZA
dc.date.accessioned2021-07-27T19:43:49Z
dc.date.available2021-07-27T19:43:49Z
dc.date.issued2019
dc.descriptionCITATION: Jack, B. U., et al. 2019. Adipose tissue as a possible therapeutic target for polyphenols : a case for Cyclopia extracts as anti-obesity nutraceuticals. Biomedicine and Pharmacotherapy, 120:109439, doi:1016/j.biopha.2019.109439.
dc.descriptionThe original publication is available at https://www.sciencedirect.com
dc.description.abstractENGLISH ABSTRACT: Obesity is a significant contributor to increased morbidity and premature mortality due to increasing the risk of many chronic metabolic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle modifications such as energy restriction and increased physical activity are highly effective first-line treatment strategies used in the management of obesity. However, adherence to these behavioral changes is poor, with an increased reliance on synthetic drugs, which unfortunately are plagued by adverse effects. The identification of new and safer anti-obesity agents is thus of significant interest. In recent years, plants and their phenolic constituents have attracted increased attention due to their health-promoting properties. Amongst these, Cyclopia, an endemic South African plant commonly consumed as a herbal tea (honeybush), has been shown to possess modulating properties against oxidative stress, hyperglycemia, and obesity. Likewise, several studies have reported that some of the major phenolic compounds present in Cyclopia spp. exhibit anti-obesity effects, particularly by targeting adipose tissue. These phenolic compounds belong to the xanthone, flavonoid and benzophenone classes. The aim of this review is to assess the potential of Cyclopia extracts as an anti-obesity nutraceutical as underpinned by in vitro and in vivo studies and the underlying cellular mechanisms and biological pathways regulated by their phenolic compounds.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0753332219330562
dc.description.versionPublisher's version
dc.format.extent23 pagesen_ZA
dc.identifier.citationJack, B. U., et al. 2019. Adipose tissue as a possible therapeutic target for polyphenols : a case for Cyclopia extracts as anti-obesity nutraceuticals. Biomedicine and Pharmacotherapy, 120:109439, doi:1016/j.biopha.2019.109439
dc.identifier.issn0753-3322 (print)
dc.identifier.otherdoi:1016/j.biopha.2019.109439
dc.identifier.urihttp://hdl.handle.net/10019.1/110775
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectObesityen_ZA
dc.subjectAdipose tissueen_ZA
dc.subjectCyclopiaen_ZA
dc.subjectPhenolic compoundsen_ZA
dc.subjectNeutriceuticals -- Weight lossen_ZA
dc.titleAdipose tissue as a possible therapeutic target for polyphenols : a case for Cyclopia extracts as anti-obesity nutraceuticalsen_ZA
dc.typeArticleen_ZA
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