Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa

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dc.contributor.authorDu Preez, K.en_ZA
dc.contributor.authorDu Plessis, L.en_ZA
dc.contributor.authorO’Connell, N.en_ZA
dc.contributor.authorHesseling, A. C.en_ZA
dc.date.accessioned2020-11-20T08:09:34Z
dc.date.available2020-11-20T08:09:34Z
dc.date.issued2018
dc.descriptionCITATION: Du Preez, K., et al. 2018. Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa. International Journal of Tuberculosis and Lung Disease, 22(9):1037-1043, doi:10.5588/ijtld.17.0893.
dc.descriptionThe original publication is available at https://www.ingentaconnect.com/content/iuatld/ijtld
dc.description.abstractSETTING: The Khayelitsha subdistrict has the highest burden of reported tuberculosis (TB) cases in Cape Town, Western Cape Province, South Africa. OBJECTIVES: To characterise the TB burden, spectrum and treatment outcomes among children managed at a district-level hospital, the Khayelitsha District Hospital. DESIGN: Retrospective medical record review of all children (age <13 years) diagnosed with TB in January–July 2014. A lay health care worker completed daily surveillance and supported linkage to TB care. Symptoms and investigations at presentation, TB disease spectrum, referral pathways and outcomes were reported. RESULTS: Most children were aged ≤2 years (84/99, 85%), 18/96 (19%) were infected with the human immunodeficiency virus, 31/91 (34%) were malnourished and 80/99 (81%) had pulmonary TB only. The majority of the children (63/80, 79%) presented with cough of acute onset (<2 weeks). Only 5/36 (14%) eligible child contacts had documentation of receiving isoniazid preventive therapy. Twelve (13%) children had bacteriologically confirmed pulmonary TB. Overall, 93/97 (96%) children successfully continued TB care after hospital discharge. Favourable TB treatment outcomes were recorded in only 77 (78%) children. CONCLUSIONS: Children with TB managed at this district-level hospital were young, and frequently had acute symptoms and substantial comorbidities. Missed opportunities for TB prevention were identified. Linkage to care support resulted in excellent continuation of TB care; however, treatment outcomes could be further improved.en_ZA
dc.description.urihttps://www.ingentaconnect.com/content/iuatld/ijtld/2018/00000022/00000009/art00012
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationDu Preez, K., et al. 2018. Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa. International Journal of Tuberculosis and Lung Disease, 22(9):1037-1043, doi:10.5588/ijtld.17.0893
dc.identifier.issn1815-7920 (online)
dc.identifier.issn1027-3719 (print)
dc.identifier.otherdoi:10.5588/ijtld.17.0893
dc.identifier.urihttp://hdl.handle.net/10019.1/108945
dc.language.isoen_ZAen_ZA
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.rights.holderThe Unionen_ZA
dc.subjectTuberculosis -- Patients -- Careen_ZA
dc.subjectHIV (Viruses) -- Diagnosisen_ZA
dc.subjectChildren of tuberculosis patients -- South Africaen_ZA
dc.titleBurden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africaen_ZA
dc.typeArticleen_ZA
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