Application of irradiation as an immunosuppressive agent

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dc.contributor.authorDu Toit, D. F.en_ZA
dc.contributor.authorHeydenrych, J. J.en_ZA
dc.date.accessioned2011-03-18T14:57:28Z
dc.date.available2011-03-18T14:57:28Z
dc.date.issued1987-04
dc.descriptionCITATION: Du Toit, D.F. & Heydenrych, J.J. 1987. Application of irradiation as an immunosuppressive agent. S Afr Med J, 71(4):445-447.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractENGLISH ABSTRACT: The concept of using total lymphoid irradiation (TLI) for immunosuppression is based on the prolonged and profound immunosuppressive effects observed after TLI in the treatment of patients with Hodgkin's disease. Pre-operative TLI of allograft recipients has been shown to be immunosuppressive when used alone or together with chemical immunosuppression. Fractionated TLI and allogeneic bone marrow injections produce stable chimaerism without graft-versus-host disease in inbred mice, rats and mongrel dogs and transplantation tolerance of skin and cardiac grafts in rats. In the primate, TLI and bone marrow injection result in significant tolerance of liver and kidney allografts. In 1959 sublethal whole-body irradiation was used as an immunosuppressive agent for the first successful related-human renal allografts between non-identical twins. Despite the dangers of myelosuppression, recent clinical experience has shown TLI to be a useful immunosuppressant for organ transplantation, allowing decreased dosage of concomitant immunosuppressive drugs.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.versionPublisher’s version
dc.format.extent3 pagesen_ZA
dc.identifier.citationDu Toit, D.F. & Heydenrych, J.J. 1987. Application of irradiation as an immunosuppressive agent. S Afr Med J, 71(4):445-447.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7441
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectImmunosuppressionen_ZA
dc.subjectAllogeneic homograftsen_ZA
dc.subjectLymphoid leukemia -- Irradiationen_ZA
dc.titleApplication of irradiation as an immunosuppressive agenten_ZA
dc.typeArticleen_ZA
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