Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial

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dc.contributor.authorFranzen, Danielen_ZA
dc.contributor.authorDiacon, Andreas H.en_ZA
dc.contributor.authorFreitag, Lutzen_ZA
dc.contributor.authorSchubert, Pawel T.en_ZA
dc.contributor.authorWright, Colleen A.en_ZA
dc.contributor.authorSchuurman, Mace M.en_ZA
dc.date.accessioned2017-08-03T06:25:01Z
dc.date.available2017-08-03T06:25:01Z
dc.date.issued2016
dc.descriptionCITATION: Franzen, D., et al. 2016. Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial. BMC Pulmonary Medicine, 16:62, doi:10.1186/s12890-016-0225-1.
dc.descriptionThe original publication is available at https://bmcpulmmed.biomedcentral.com
dc.description.abstractBackground: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronchoscopy (UB) for this purpose is limited. To evaluate feasibility and safety of UB compared to SB for diagnosis of SPL in a TB endemic region. Methods: In this prospective randomised trial we compared diagnostic yield and adverse events of UB with standard- size bronchoscopy (SB), both combined with fluoroscopy, in a cohort of patients with SPL located beyond the visible range of SB. Results: We included 40 patients (mean age 55.2 years, 45 % male) with malignant SPL ( n = 16; 40 %), tuberculous SPL ( n = 11; 27.5 %) and other benign SPL ( n = 13; 32.5 %). Mean procedure time in UB and SB was 30.6 and 26.0 min, respectively ( p = 0.15). By trend, adverse events were recorded more often with UB than with SB (30.0 vs. 5.0 %, p = 0.091), including extensive coughing ( n = 2), blocked working channel ( n = 2), and arterial hypertension requiring therapeutic intervention ( n = 1), all with UB. The overall diagnostic yield of UB compared to SB was 55.0 % vs. 80.0 %, respectively ( p = 0.18). Sensitivity for the diagnosis of malignancy of UB and SB was 50.0 % and 62.5 %, respectively ( p =0.95). Conclusion: UB is not superior to SB for the evaluation of SPL in a region endemic with tuberculosis, when combined with fluoroscopic guidance only. Trial registration: ClinicalTrials.gov (Identifier: NCT02490059).en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttps://bmcpulmmed.biomedcentral.com/track/pdf/10.1186/s12890-016-0225-1?site=bmcpulmmed.biomedcentral.com
dc.description.versionPublisher's version
dc.format.extent7 pagesen_ZA
dc.identifier.citationFranzen, D., et al. 2016. Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial. BMC Pulmonary Medicine, 16:62, doi:10.1186/s12890-016-0225-1
dc.identifier.issn1471-2466 (online)
dc.identifier.otherdoi:10.1186/s12890-016-0225-1
dc.identifier.urihttp://hdl.handle.net/10019.1/102040
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectLung canceren_ZA
dc.subjectBronchoscopyen_ZA
dc.subjectPulmonary diseasesen_ZA
dc.subjectTuberculosis -- Histologyen_ZA
dc.titleUltrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trialen_ZA
dc.typeArticleen_ZA
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