Bone health in patients undergoing surgery for primary hyperparathyroidism at Tygerberg Hospital, Cape Town, South Africa

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dc.contributor.authorBudgea, Men_ZA
dc.contributor.authorConradie, Wen_Za
dc.contributor.authorBeviss-Challinor, Ken_ZA
dc.contributor.authorMartin, Len_ZA
dc.contributor.authorConradie, Men_ZA
dc.contributor.authorCoetzee, Aen_ZA
dc.date.accessioned2023-03-23T05:54:42Zen_ZA
dc.date.available2023-03-23T05:54:42Zen_ZA
dc.date.issued2021-03en_ZA
dc.descriptionCITATION:Budgea, M, et al. 2021. Bone health in patients undergoing surgery for primary hyperparathyroidism at Tygerberg Hospital, Cape Town, South Africa. Journal of Endocrinology, Metabolism and Diabetes of South Africa 26(1):16–23 doi.10.1080/16089677.2020.1843841en_ZA
dc.descriptionThe original publication is available at: .jemdsa.co.zaen_ZA
dc.description.abstractBackground: Increased bone resorption is a well-described consequence of primary hyperparathyroidism (PHPT). In South Africa, little is known about the impact of PHPT on skeletal health. Objective: To determine the prevalence of decreased bone mineral density (BMD), vertebral fractures and osteitis fibrosa cystica in patients with PHPT who underwent parathyroidectomy. Methods: Retrospective study of patients who underwent parathyroidectomy for PHPT at Tygerberg Hospital in Cape Town, from January 2010 to December 2019. Clinical, biochemical and BMD parameters are described. Results: Final analysis included 56 patients (median age 63.5 years; 80.4% female). Initial calcium, parathyroid hormone (PTH) and 25-hydroxyvitamin D (25[OH]D) levels were 2.93 mmol/l, 19.4 pmol/l and 34.0 nmol/l, respectively. Of the total cohort, 71.4% had decreased BMD. The prevalence of osteoporosis and osteopenia in postmenopausal women and men ≥ 50 years was 50.0% and 39.1% respectively; low bone mass for age in premenopausal women and men < 50 years was 20.0%. Vertebral fractures were seen in 21.2% of patients on radiography. Osteitis fibrosa cystica was present in five patients (9.6%). PTH levels were significantly elevated in patients with osteoporosis compared with those with normal BMD (36.4 vs. 16.1 pmol/l; p = 0.02). Conclusion: Two-thirds of patients who underwent parathyroidectomy for PHPT had decreased BMD, with osteoporosis present in 50% of postmenopausal women and older men. One in five had vertebral fractures. These findings underscore the importance of skeletal assessment in the management of PHPT.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent8 pagesen_ZA
dc.identifier.citationBudgea, M, et al. 2021. Bone health in patients undergoing surgery for primary hyperparathyroidism at Tygerberg Hospital, Cape Town, South Africa. Journal of Endocrinology, Metabolism and Diabetes of South Africa 26(1):16–23 doi.10.1080/16089677.2020.1843841en_ZA
dc.identifier.issn1608-9677 (print)en_ZA
dc.identifier.issn2220-1009 (online)en_ZA
dc.identifier.otherdoi.10.1080/16089677.2020.1843841en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126698en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherJemdsaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBone resorptionen_ZA
dc.subjectBone densitometryen_ZA
dc.subjectFracturesen_ZA
dc.subjectOsteoporosisen_ZA
dc.subjectParathyroid hormoneen_ZA
dc.subjectHyperparathyroidismen_ZA
dc.subjectCalciumen_ZA
dc.subjectUCTDen_ZA
dc.titleBone health in patients undergoing surgery for primary hyperparathyroidism at Tygerberg Hospital, Cape Town, South Africaen_ZA
dc.typeArticleen_ZA
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