Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment

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dc.contributor.authorMentoor, Ilzeen_ZA
dc.contributor.authorEngelbrecht, Anna-Marten_ZA
dc.contributor.authorVan Jaarsveld, Paul J.en_ZA
dc.contributor.authorNell, Theo A.en_ZA
dc.contributor.editorVella, Veronicaen_ZA
dc.date.accessioned2019-03-28T12:40:03Z
dc.date.available2019-03-28T12:40:03Z
dc.date.issued2018-12-11
dc.descriptionCITATION: Mentoor, I., et al. 2018. Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment. Frontiers in Endocrinology, 9:758, doi:10.3389/fendo.2018.00758.en_ZA
dc.descriptionThe original publication is available at http://journal.frontiersin.org/journal/endocrinologen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractExcess adipose tissue is a hallmark of an overweight and/or obese state as well as a primary risk factor for breast cancer development and progression. In an overweight/obese state adipose tissue becomes dysfunctional due to rapid hypertrophy, hyperplasia, and immune cell infiltration which is associated with sustained low-grade inflammation originating from dysfunctional adipokine synthesis. Evidence also supports the role of excess adipose tissue (overweight/obesity) as a casual factor for the development of chemotherapeutic drug resistance. Obesity-mediated effects/modifications may contribute to chemotherapeutic drug resistance by altering drug pharmacokinetics, inducing chronic inflammation, as well as altering tumor-associated adipocyte adipokine secretion. Adipocytes in the breast tumor microenvironment enhance breast tumor cell survival and decrease the efficacy of chemotherapeutic agents, resulting in chemotherapeutic resistance. A well-know chemotherapeutic agent, doxorubicin, has shown to negatively impact adipose tissue homeostasis, affecting adipose tissue/adipocyte functionality and storage. Here, it is implied that doxorubicin disrupts adipose tissue homeostasis affecting the functionality of adipose tissue/adipocytes. Although evidence on the effects of doxorubicin on adipose tissue/adipocytes under obesogenic conditions are lacking, this narrative review explores the potential role of obesity in breast cancer progression and treatment resistance with inflammation as an underlying mechanism.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fendo.2018.00758/full
dc.description.versionPublisher's versionen_ZA
dc.format.extent16 pages : illustrationsen_ZA
dc.identifier.citationMentoor, I., et al. 2018. Chemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironment. Frontiers in Endocrinology, 9:758, doi:10.3389/fendo.2018.00758en_ZA
dc.identifier.issn1664-2392 (online)
dc.identifier.otherdoi:10.3389/fendo.2018.00758
dc.identifier.urihttp://hdl.handle.net/10019.1/105556
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBreast tumor cellsen_ZA
dc.subjectAdipose tissueen_ZA
dc.subjectBreast cancer -- Treatmenten_ZA
dc.subjectChemotherapeutic drug resistanceen_ZA
dc.titleChemoresistance : intricate interplay between breast tumor cells and adipocytes in the tumor microenvironmenten_ZA
dc.typeArticleen_ZA
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