Synthesis of pyrrolocarbazoles with N-substituted alkynyl-, alkylcyano- and alkylhydroxyl-groups

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dc.contributor.authorVan der Westhuyzen, Alet E.en_ZA
dc.contributor.authorHadjegeorgiou, Kathyen_ZA
dc.contributor.authorGreen, Ivan R.en_ZA
dc.contributor.authorPelly, Stephen C.en_ZA
dc.contributor.authorVan Otterlo, Willem A. L.en_ZA
dc.date.accessioned2022-01-18T12:44:32Z
dc.date.available2022-01-18T12:44:32Z
dc.date.issued2020
dc.descriptionCITATION: Van der Westhuyzen, A. E. et al. 2020. Synthesis of pyrrolocarbazoles with N-substituted alkynyl-, alkylcyano- and alkylhydroxyl-groups. Arkivoc, v:129-147, doi:10.24820/ark.5550190.p011.412.
dc.descriptionThe original publication is available at https://www.arkat-usa.org
dc.description.abstractENGLISH ABSTRACT: Due to their involvement in almost all stages of cellular life, kinase biomolecular catalysts have been linked to cancer development and, thus, remain attractive drug targets for cancer therapeutics. 6-(3ꞌ-Hydroxypropyl)-, 6-(2ꞌ-hydroxyethyl)-, 6-(2ꞌ-propynyl)- and 6-(3ꞌ-propanenitrile)-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were synthesized as potential small molecule EGFR kinase inhibitors. The pyrrolocarbazole compounds were synthesized by way of a Diels-Alder approach involving N-alkylated 2-vinyl-1H-indole and maleimide as starting materials followed by aromatization with MnO2.en_ZA
dc.description.versionPublisher's version
dc.format.extent19 pagesen_ZA
dc.identifier.citationVan der Westhuyzen, A. E. et al. 2020. Synthesis of pyrrolocarbazoles with N-substituted alkynyl-, alkylcyano- and alkylhydroxyl-groups. Arkivoc, v:129-147, doi:10.24820/ark.5550190.p011.412.
dc.identifier.issn1551-7012 (online)
dc.identifier.otherdoi:10.24820/ark.5550190.p011.412
dc.identifier.urihttp://hdl.handle.net/10019.1/124106
dc.language.isoen_ZAen_ZA
dc.publisherARKAT USAen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectPyrrolocarbazoleen_ZA
dc.subjectKinase inhibitors -- Receptoren_ZA
dc.subjectDiels-Alder reactionen_ZA
dc.subjectAromatizationen_ZA
dc.titleSynthesis of pyrrolocarbazoles with N-substituted alkynyl-, alkylcyano- and alkylhydroxyl-groupsen_ZA
dc.typeArticleen_ZA
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