Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort

dc.contributor.authorLeisegang, Kristianen_ZA
dc.contributor.authorBouic, Patrick J. D.en_ZA
dc.contributor.authorMenkveld, Roelofen_ZA
dc.contributor.authorHenkel, Ralf R.en_ZA
dc.date.accessioned2016-07-08T12:41:56Z
dc.date.available2016-07-08T12:41:56Z
dc.date.issued2014
dc.descriptionCITATION: Leisegang, K., et al. 2014. Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort. Reproductive Biology and Endocrinology, 12(34): 1-12, doi: 10.1186/1477-7827-12-34.
dc.descriptionThe original publication is available at http://rbej.biomedcentral.com
dc.description.abstractBackground: Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes axis, contributing to the regulation of male reproductive potential and overall wellbeing. These hormones are also present in semen influencing sperm functions. Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated. Methods: This small case controlled study assessed serum and seminal concentrations of insulin, leptin and glucose in obese (BMI > =30; n = 23) and non-obese (BMI < 30; n = 19) males. Following a detailed medical history and examination, participants meeting the inclusion criteria were entered for data analysis. Body parameters such as BMI, waist and hip circumference and the waist hip ratio were measured. Serum and semen samples were collected and assayed for insulin, leptin and glucose. Semen samples also underwent a standard semen analysis, with sperm mitochondrial membrane potential (MMP) and DNA fragmentation (DF). Results: Obesity was associated with increased serum and seminal insulin and leptin, with no significant difference in seminal glucose. Serum and seminal concentrations of insulin and leptin were positively correlated. Furthermore, obesity was associated with decreased sperm concentration, sperm vitality and increased MMP and DF, with a non-significant impact on motility and morphology. Conclusions: Hyperinsulinaemia and hyperleptinaemia are associated with increased seminal insulin and leptin concentrations, which may negatively impact male reproductive function in obesity. Insulin was also found to be highly concentrated in the seminal plasma of both groups. This data will contribute to the contradictive information available in the literature on the impact of obesity and male reproduction.en_ZA
dc.description.urihttp://rbej.biomedcentral.com/articles/10.1186/1477-7827-12-34
dc.description.versionPublisher's version
dc.format.extent12 pages
dc.identifier.citationLeisegang, K., et al. 2014. Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort. Reproductive Biology and Endocrinology, 12(34): 1-12, doi: 10.1186/1477-7827-12-34
dc.identifier.issn1477-7827 (online)
dc.identifier.issn1477-7827 (print)
dc.identifier.otherdoi: 10.1186/1477-7827-12-34
dc.identifier.urihttp://hdl.handle.net/10019.1/99119
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectMale obesity -- Health aspectsen_ZA
dc.subjectMale reproductive healthen_ZA
dc.subjectInsulin resistanceen_ZA
dc.subjectLeptinen_ZA
dc.subjectGlucoseen_ZA
dc.subjectFertility, Humanen_ZA
dc.titleObesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohorten_ZA
dc.typeArticleen_ZA
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