The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron-deficiency

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dc.contributor.authorSmuts, C. M.
dc.contributor.authorTichelaar, H. Y.
dc.contributor.authorVan Jaarsveld, P. J.
dc.contributor.authorBadenhorst, C. J.
dc.contributor.authorKruger, M.
dc.contributor.authorLaubscher, R.
dc.contributor.authorMansvelt, E. P. G.
dc.contributor.authorBenade, A. J. S.
dc.date.accessioned2011-05-15T16:17:45Z
dc.date.available2011-05-15T16:17:45Z
dc.date.issued1994
dc.description.abstractAn intervention study was designed to evaluate the fatty acid (FA) status of children aged 6-11 years before and after iron fortification. Iron deficient (ID) and matched controls without ID (n = 30) were selected. All children received soup (160 mL) fortified with 20 mg iron and 100 mg vitamin C for 15 weeks on school days. Measurements before and after intervention included dietary intake, haematological and iron status and FA composition of plasma and erythrocyte membranes (EMBs). The prevalence of low plasma ferritin concentration and transferrin saturation decreased in the ID children by 40% and 56%, respectively, with intervention. Plasma FAs reflected dietary FA intake. In comparison with controls, the ID group presented with increased percentage total saturated FAs (SFAs; p = 0.0002) in their EMB phosphatidylcholine (PC) and reduced percentage total polyunsaturated FAs (PUFAs; p = 0.0037) before intervention. Lower total n-3 FAs (p = 0.0070) including eicosapentaenoic acid (EPA; p = 0.0034), docosapentaenoic acid (DPA; p = 0.0048) and docosahexaenoic acid (DHA; p = 0.0058) were observed in the ID group. The EMB phosphatidylethanolamine (PEA) of the ID children presented with lower percentages of α-linolenic acid (ALA; p = 0.0001), EPA (p = 0.0051) and DHA (p = 0.0084) compared to controls before intervention. Iron intervention was associated with an increase (p < 0.05) in the percentage of n-3 FAs in the EMB-PC and -PEA of the ID group to percentages comparable to that in the control group. It appears that iron status can influence FA metabolism of specific n-3 FAs in the EMBs of young children.
dc.description.versionArticle
dc.identifier.citationProstaglandins Leukotrienes and Essential Fatty Acids
dc.identifier.citation51
dc.identifier.citation4
dc.identifier.issn09523278
dc.identifier.other10.1016/0952-3278(94)90192-9
dc.identifier.urihttp://hdl.handle.net/10019.1/14359
dc.subjectfatty acid
dc.subjectferritin
dc.subjecticosanoid
dc.subjectiron
dc.subjectpolyunsaturated fatty acid
dc.subjecttransferrin
dc.subjectarticle
dc.subjectcell membrane
dc.subjectchemical composition
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectdietary intake
dc.subjecterythrocyte membrane
dc.subjectfat intake
dc.subjectfatty acid metabolism
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectiron deficiency
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectschool child
dc.subjectChild
dc.subjectDiet
dc.subjectErythrocyte Membrane
dc.subjectFatty Acids
dc.subjectFatty Acids, Omega-3
dc.subjectFatty Acids, Unsaturated
dc.subjectFemale
dc.subjectHemoglobins
dc.subjectHuman
dc.subjectIron
dc.subjectMale
dc.subjectMembrane Lipids
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransferrin
dc.subjectPisum sativum
dc.titleThe effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron-deficiency
dc.typeArticle
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