Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase

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dc.contributor.authorTheron, C. N.en_ZA
dc.contributor.authorLubbe, S.en_ZA
dc.contributor.authorVan Zyl, A.en_ZA
dc.date.accessioned2011-03-18T14:57:49Z
dc.date.available2011-03-18T14:57:49Z
dc.date.issued1979
dc.descriptionCITATION: Theron, C. N., Lubbe, S. & Van Zyl, A. 1979. Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase. South African Medical Journal, 56:670-675.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractMyeloperoxidase with an A420!280 ratio of 0,48 was prepared from normal human leucocytes. This partially purified preparation catalysed guaiacol oxidation, iodination of bovine serum albumin and de-iodination of 1251-thyroxine. Non-steroidal anti-inflammatory drugs (naproxen, indomethacin and f1ufenamic acid) showed a significant inhibitory effect on myeloperoxidase-catalysed iodination at concentrations of 10"4M and higher. Guaiacol also inhibited myeloperoxidase-catalysed iodination, and its iodination inhibition curve was nearly identical to that obtained with the anti-inflammatory drugs. At concentrations between 10"'M and 10"M the antiinflammatory drugs had very little or no effect on thyroxine de-iodination. Flufenamic acid and indomethacin, however, inhibited de-iodination significantly at a concentration of 10'M. It is postulated that non-steroidal anti-inflammatory drugs may inhibit myeloperoxidase-catalysed protein iodination by acting as oxidizable cofactors which compete with other oxidiza'ble substrates for oxidants formed by the peroxidase-hydrogen peroxide complex. In view of this and because the myeloperoxidase-hydrogen peroxide system may be involved in inflammatory tissue damage, the possibility should be considered that the action of non-steroidal anti-inflammatory drugs is at least partly attributable to a radical scavenging effect or to sequestration of oxidants.
dc.description.versionPublisher’s version
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7668
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectAnti-inflammatory agentsen_ZA
dc.titleInhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidaseen_ZA
dc.typeArticle
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