Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion

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dc.contributor.authorVan Rensburg, Lyneen_ZA
dc.contributor.authorVan Zyl, Johann M,en_ZA
dc.contributor.authorSmith, Johanen_ZA
dc.contributor.authorGoussard, Pierreen_ZA
dc.date.accessioned2019-12-09T06:10:26Z
dc.date.available2019-12-09T06:10:26Z
dc.date.issued2019-12-05
dc.date.updated2019-12-08T05:17:33Z
dc.descriptionCITATION: Van Rensburg, L., et al. 2019. Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion. BMC Pulmonary Medicine, 19:236, doi:10.1186/s12890-019-1006-4.
dc.descriptionThe original publication is available at https://bmcpulmmed.biomedcentral.com
dc.description.abstractBackground: Bronchoalveolar lavage is a useful bronchoscopy technique. However, studies in “normal” children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on the bronchoalveolar cellular components are limited. Methods: Thirty children, aged 3 to 14 years, underwent diagnostic bronchoscopy and bronchoalveolar lavage. Differential cytology, cytokine and chemokine measurements were performed on the fluid after exogenous surfactant exposure. The aim of the study was to investigate the potential anti-inflammatory effects of exogenous surfactants on the bronchoalveolar lavage fluid, specifically alveolar macrophages of healthy South African children. Results: Alveolar macrophages were the predominant cellular population in normal children. Patients with inflammatory pneumonopathies had significantly more neutrophils. Levels of inflammatory cytokines were significantly lower after exogenous surfactant exposure. Moreover, IL-10 and IL-12 cytokine secretion increased after exogenous surfactant exposure. Conclusion: This study provides the first data on bronchoalveolar lavage of healthy South African children. Bronchoalveolar lavage fluid from patients with pulmonary inflammation was characterised by neutrophilia. Finally, we propose that exogenous surfactant treatment could help alleviate inflammation in diseased states where it occurs in the tracheobronchial tree.
dc.description.urihttps://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1006-4
dc.description.versionPublisher's version
dc.format.extent5 pagesen_ZA
dc.identifier.citationVan Rensburg, L., et al. 2019. Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretion. BMC Pulmonary Medicine, 19:236, doi:10.1186/s12890-019-1006-4
dc.identifier.issn1471-2466 (online)
dc.identifier.otherdoi:10.1186/s12890-019-1006-4
dc.identifier.urihttp://hdl.handle.net/10019.1/106897
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBronchoscopyen_ZA
dc.subjectBronchoalveolar lavageen_ZA
dc.subjectCytokines -- Secretionen_ZA
dc.titleEffect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages’ cytokine secretionen_ZA
dc.typeArticle
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