Serum antibodies to human T-cell leukaemia virus type I in different ethnic groups and in non-human primates in South Africa

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dc.contributor.authorBecker, W. B.en_ZA
dc.contributor.authorBecker, M. L. B.en_ZA
dc.contributor.authorHomma, T.en_ZA
dc.date.accessioned2011-03-18T14:57:35Z
dc.date.available2011-03-18T14:57:35Z
dc.date.issued1985
dc.descriptionCITATION: Becker, W. B., Becker, M. L. B. & Homma, T. 1985. Serum antibodies to human T-cell leukaemia virus type I in different ethnic groups and in non-human primates in South Africa. South African Medical Journal, 67:445-449.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractThe prevalence of humoral antibodies to human T-cell leukaemia virus type I (HTLV-I) was investigated in different ethnic groups and in non-human primates in South Africa. Serum antibody levels were determined by enzyme-linked immunosorbent assay (ELISA) using either disrupted whole HTLV-I or purified p24 core protein (p24 HTLV-I) as antigens. ELISA was complemented by direct radio-immunoprecipitation assays using either purified iodinated p24 HTLV-I or radiolabelled lysates of an HTLV-producing cell line as antigen followed by sodium dodecyl sulphate polyacrylamide gel electrophoresis of the immunoprecipitates, and by immunofluorescence using the HTLV-I-producing cell line HUT-102 as antigen. Antibodies were demonstrated in 3,5% of Asians, 3,5% of blacks and 4,1% of coloureds, but not in whites, and also in 29% of vervet monkeys and 33% of baboons. We conclude that HTLV-I or closely related viruses cause widespread infection in non-human primates in South Africa and in a lower percentage of humans, including apparently healthy blood donors. We are currently isolating retroviruses from seropositive reactors and investigating the possible relevance to disease in South Africa.
dc.description.versionPublisher’s version
dc.format.extent5 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7520
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectLeukemiaen_ZA
dc.titleSerum antibodies to human T-cell leukaemia virus type I in different ethnic groups and in non-human primates in South Africaen_ZA
dc.typeArticle
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