Serum amyloid A and inflammasome activation : a link to breast cancer progression?

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dc.contributor.authorFourie, Carlaen_ZA
dc.contributor.authorShridas, Preethaen_ZA
dc.contributor.authorDavis, Tanjaen_ZA
dc.contributor.authorde Villiers, Willem J. S.en_ZA
dc.contributor.authorEngelbrecht, Anna-Marten_ZA
dc.date.accessioned2022-06-20T14:23:51Zen_ZA
dc.date.available2022-06-20T14:23:51Zen_ZA
dc.date.issued2020-10-27en_ZA
dc.descriptionCITATION: Fourie, C. et al. 2021.Serum amyloid A and inflammasome activation: A link to breast cancer progression? Cytokine & Growth Factor Reviews, 59:62-70. doi:10.1016/j.cytogfr.2020.10.006en_ZA
dc.descriptionThe original publication is available at https://www.sciencedirect.com/journal/cytokine-and-growth-factor-reviewsen_ZA
dc.description.abstractBreast cancer is the most frequently diagnosed cancer in women globally. Although there have been many significant advances made in the diagnosis and treatment of breast cancer, numerous unresolved challenges remain, which include prevention, early diagnosis, metastasis and recurrence. The role of inflammation in cancer development is well established and is believed to be one of the leading hallmarks of cancer progression. Recently, the role of the inflammasome, a cytosolic multiprotein complex, has received attention in different cancers. By contributing to the activation of inflammatory cytokines the inflammasome intensifies the inflammatory cascade. The inflammasome can be activated through several pathways, which include the binding of pattern associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) to toll-like receptors (TLRs). Serum amyloid A (SAA), a non-specific acute-phase protein, can function as an endogenous DAMP by binding to pattern recognition receptors like TLRs on both breast cancer cells and cancer associated fibroblasts (CAFs). SAA can thus stimulate the production of IL-1β, thereby creating a favourable inflammatory environment to support tumour growth. The aim of this review is to highlight the possible role of SAA as an endogenous DAMP in the tumour microenvironment (TME) thereby promoting breast cancer growth through the activation of the NLRP3 inflammasome.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1359610120302203?via%3Dihuben_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationCITATION: Fourie, C. et al. 2021.Serum amyloid A and inflammasome activation: A link to breast cancer progression? Cytokine & Growth Factor Reviews, 59:62-70. doi:10.1016/j.cytogfr.2020.10.006en_ZA
dc.identifier.issn1359-6101 (print)en_ZA
dc.identifier.otherdoi:10.1016/j.cytogfr.2020.10.006en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125389en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderElsevieren_ZA
dc.subjectBreast cancer -- Diagnosisen_ZA
dc.subjectInflammasomeen_ZA
dc.subjectInterleukin-1en_ZA
dc.subjectCancer -- Treatmenten_ZA
dc.subjectCarcinogenesisen_ZA
dc.titleSerum amyloid A and inflammasome activation : a link to breast cancer progression?en_ZA
dc.typeArticleen_ZA
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