Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression

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dc.contributor.authorKader, Rehanaen_ZA
dc.contributor.authorGovender, Rajenen_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorKoch, John Randyen_ZA
dc.contributor.authorParry, Charlesen_ZA
dc.date.accessioned2016-08-29T07:57:05Z
dc.date.available2016-08-29T07:57:05Z
dc.date.issued2015-05
dc.descriptionCITATION: Kader, R., et al. 2015. Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PLoS ONE, 10(5):1-12, doi:10.1371/journal.pone.0125088.en_ZA
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractThe objective of this study was to understand the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression among HIV patients. A cross-sectional study design was used. A total of 1503 patients attending HIV clinics in Cape Town, South Africa were screened for problematic substance use. A sub-sample of 607 patients (303 patients who screened positive for problematic substance use and 304 who did not) participated in this study. Hazardous or harmful alcohol use and problematic drug use predicted missing and stopping ARVs which, in turn, was associated with a decrease in CD4 counts and more rapid HIV-disease progression and poorer health outcomes in people living with HIV/AIDS (PLWHA). The findings of this study underscore the need for an integrated approach to managing substance-use disorders in PLWHA.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent12 pages
dc.identifier.citationKader, R., et al. 2015. Understanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progression. PLoS ONE, 10(5):1-12, doi:10.1371/journal.pone.0125088
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0125088
dc.identifier.urihttp://hdl.handle.net/10019.1/99496
dc.language.isoen_ZAen_ZA
dc.provenanceZM201609en_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectAlcohol useen_ZA
dc.subjectHIV patientsen_ZA
dc.subjectDrug abuseen_ZA
dc.subjectUnemploymenten_ZA
dc.titleUnderstanding the impact of hazardous and harmful use of alcohol and/or other drugs on ARV adherence and disease progressionen_ZA
dc.typeArticleen_ZA
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