Toxicological screening for drugs of abuse in samples adulterated with household chemicals

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dc.contributor.authorUebel, Reinhard A.en_ZA
dc.contributor.authorWium, Cherylynn A.en_ZA
dc.date.accessioned2011-03-18T14:57:03Z
dc.date.accessioned2011-03-18T14:57:03Z
dc.date.available2011-03-18T14:57:03Z
dc.date.available2011-03-18T14:57:03Z
dc.date.issued2002
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractObjectives. Urine samples that tested positive for two drugs of abuse, namely cannabis and methaqualone, were reassayed in the presence or absence of common household chemicals: Jik (sodium hypochlorite), Dettol (chloroxylenol), G-cide Plus (glutaraldehyde), Perle Hand Soap, ethanol, isopropanol and peroxide (20 volumes). These chemicals are frequently used for the adulteration of urine samples. Setting. Department of Pharmacology, University of Stellenbosch. Methods. Household chemicals, at three different concentrations, were added to urine samples that tested positive for methaqualone and cannabis. Samples were re-analysed on an ETS Plus Analyser (Syva company, San Jose, Ca.) using Emit drugs-of-abuse urine test reagents. Results. Most of the chemicals tested influenced the outcome of positive toxicological screening results for these drugs. G-cide (glutaraldehyde) and Perle Hand Soap had the largest effect (false-negative) on the methaqualone test. Dettol (chloroxylenol) and Perle Hand Soap had the largest effect on the cannabis test. Higher concentrations of the adulterant were not always an indication of the extent of modification of the test result. The addition of certain chemicals (ethanol, isopropanol and peroxide) to the urine samples tested for methaqualone interfered with the test to such an extent that it gave invalid test results.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.versionPublisher’s version
dc.format.extent3 pagesen_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7159
dc.identifier.urihttp://hdl.handle.net/10019.1/7159
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderSouth African Medical Journalen_ZA
dc.subjectToxicological testingen_ZA
dc.subjectDrug abuse screeningen_ZA
dc.subjectUrine -- Analysisen_ZA
dc.subjectSubstance abuse -- Diagnosisen_ZA
dc.titleToxicological screening for drugs of abuse in samples adulterated with household chemicalsen_ZA
dc.typeArticle
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