Are early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal
dc.contributor.author | Van Der Merwe J.L. | |
dc.contributor.author | Hall D.R. | |
dc.contributor.author | Wright C. | |
dc.contributor.author | Schubert P. | |
dc.contributor.author | Grove D. | |
dc.date.accessioned | 2011-05-15T16:16:36Z | |
dc.date.available | 2011-05-15T16:16:36Z | |
dc.date.issued | 2010 | |
dc.description.abstract | Objective. To compare histopathological differences in placentas from early- and late-onset preeclampsia, as well as late-onset preeclampsia and normal term deliveries. Methods. This prospective study was performed at Tygerberg Hospital, a secondary and tertiary referral center in South Africa. Placentas from 100 women, 25 each with early and late-onset preeclampsia, and an equal number of controls matched for gestational age, underwent routine preparation and were evaluated independently by two pathologists in a strictly predetermined, standardized manner. Results. Compared to late preeclampsia, placentas in the early preeclampsia group were smaller (p < 0.01), had more infarction (odds ratio [OR] 4.03, 95 confidence interval [CI] 1.213.5) and inappropriate maturation (OR 16.62, 95 CI 4.168.0). Placentas from the late-onset preeclampsia group showed increased decidual arteriopathy (OR 5.09, 95 CI 1.4517.92) and abruptio placentae (OR 5.41, 95 CI 1.0128.79) compared to controls. Conclusions. The early- and late-onset preeclampsia placentas showed clear histopathological differences, whereas late-onset preeclampsia and normal term placentas differed less. These findings support the contention that early- and late-onset preeclampsia are different subclasses of disease. © 2010 Informa Healthcare USA, Inc. | |
dc.description.version | Article | |
dc.identifier.citation | Hypertension in Pregnancy | |
dc.identifier.citation | 29 | |
dc.identifier.citation | 4 | |
dc.identifier.issn | 10641955 | |
dc.identifier.other | 10.3109/10641950903572282 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/13854 | |
dc.subject | adult | |
dc.subject | artery disease | |
dc.subject | article | |
dc.subject | comparative study | |
dc.subject | delivery | |
dc.subject | early onset preeclampsia | |
dc.subject | female | |
dc.subject | gestational age | |
dc.subject | heart infarction | |
dc.subject | histopathology | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | late onset preeclampsia | |
dc.subject | major clinical study | |
dc.subject | pathology | |
dc.subject | placenta | |
dc.subject | preeclampsia | |
dc.subject | prospective study | |
dc.subject | solutio placentae | |
dc.subject | South Africa | |
dc.subject | Adult | |
dc.subject | Case-Control Studies | |
dc.subject | Female | |
dc.subject | Gestational Age | |
dc.subject | Humans | |
dc.subject | Odds Ratio | |
dc.subject | Placenta | |
dc.subject | Pre-Eclampsia | |
dc.subject | Pregnancy | |
dc.title | Are early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal | |
dc.type | Article |