The use of the polymerase chain reaction test in the diagnosis of tuberculosis

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dc.contributor.authorVan Helden, P. D.en_ZA
dc.contributor.authorDu Toit, R.en_ZA
dc.contributor.authorJordaan, A.en_ZA
dc.contributor.authorTaljaard, B.en_ZA
dc.contributor.authorPitout, J.en_ZA
dc.contributor.authorVictor, T.en_ZA
dc.date.accessioned2011-03-18T14:57:17Z
dc.date.available2011-03-18T14:57:17Z
dc.date.issued1991
dc.descriptionCITATION: Van Helden, P. D. et al. 1991. The use of the polymerase chain reaction test in the diagnosis of tuberculosis. South African Medical Journal, 80:515-516.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractCurrent techniques for laboratory diagnosis of tuberculosis have some serious limitations. These include the high cost and time required for the current assays. The development of a rapid, sensitive, specific and low-cost assay is therefore of considerable importance. We report here the development and laboratory testing of a polymerase chain reaction DNA-based diagnostic test for the presence of Mycobacterium tuberculosis in sputum. The assay shows a high level of sensitivity and specificity and requires considerably less capital, consumables and time inputs than existing laboratory tests. We believe this technology is ready for large-scale evaluation and use, particularly in hospital-based laboratories.
dc.description.versionPublisher’s version
dc.format.extent2 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7312
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectTuberculosis -- Diagnosisen_ZA
dc.subjectPolymerase chain reactionen_ZA
dc.titleThe use of the polymerase chain reaction test in the diagnosis of tuberculosisen_ZA
dc.typeArticle
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