Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study

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dc.contributor.authorWiseman, C. A.en_ZA
dc.contributor.authorMandalakas, A. M.en_ZA
dc.contributor.authorKirchner, H. L.en_ZA
dc.contributor.authorGie, R. P.en_ZA
dc.contributor.authorSchaaf, H. Simonen_ZA
dc.contributor.authorWalters, E.en_ZA
dc.contributor.authorHesseling, A. C.en_ZA
dc.contributor.otherPaediatrics and Child Healthen_ZA
dc.date.accessioned2016-07-11T11:43:14Z
dc.date.available2016-07-11T11:43:14Z
dc.date.issued2015-04
dc.descriptionCITATION: Wiseman, C. A. et al. 2015. Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study. International Journal of Tuberculosis and Lung Disease, 19(4):446–453, doi:10.5588/ijtld.14.0585.en_ZA
dc.descriptionThe original publication is available at http://www.ncbi.nlm.nih.gov/pubmed/25860001en_ZA
dc.description.abstractBACKGROUND: International (National Institutes of Health [NIH]) case definitions have been proposed for paediatric tuberculosis (TB) diagnostic studies. The relevance of these definitions for contact tracing studies is unknown. METHODS: We developed case definitions for a community-based contact tracing diagnostic study. We compare disease certainty using protocol-defined and NIH case definitions and describe TB disease spectrum and severity. RESULTS: There were 111 potential disease episodes in 109 (21% human immunodeficiency virus [HIV] infected) of 1093 children enrolled. Based on NIH definitions, there were 8 confirmed, 12 probable, 17 possible and 3 unlikely TB and 2 non-TB episodes. Using protocol case definitions, there were 23 episodes of confirmed, 36 probable, 27 possible and 0 unlikely TB and 21 non-TB. Of 111 potential episodes, 69 were unclassifiable using the NIH definition, while 4 were unclassifiable using the protocol definition. Agreement between definitions was 0.30 (95%CI 0.23-0.38). There were 62 episodes (72%) of non-severe and 24 (28%) of severe TB. CONCLUSIONS: The NIH definition had limited applicability to household contact studies, despite the wide spectrum of disease observed. Further research is needed to develop case definitions relevant to different research settings, including contact investigation to capture the wide spectrum of paediatric TB in clinical research.en_ZA
dc.description.urihttp://www.ingentaconnect.com/content/iuatld/ijtlden_ZA
dc.description.versionPost-printen_ZA
dc.format.extent29 pages
dc.identifier.citationWiseman, C. A. et al. 2015. Novel application of NIH case definitions in a paediatric tuberculosis contact investigation study. International Journal of Tuberculosis and Lung Disease, 19(4):446–453, doi:10.5588/ijtld.14.0585.en_ZA
dc.identifier.issn1815-7920 (online)
dc.identifier.issn1027-3719 (print)
dc.identifier.otherdoi:10.5588/ijtld.14.0585
dc.identifier.urihttp://hdl.handle.net/10019.1/99124
dc.language.isoen_ZA
dc.publisherInternational Union Against Tuberculosis and Lung Diseaseen_ZA
dc.rights.holderInternational Union Against Tuberculosis and Lung Diseaseen_ZA
dc.subjectTuberculosis in children -- Treatmenten_ZA
dc.subjectTuberculosis in children -- Diagnosisen_ZA
dc.titleNovel application of NIH case definitions in a paediatric tuberculosis contact investigation studyen_ZA
dc.typeArticleen_ZA
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