A serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contacts

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dc.contributor.authorDuffy, Fergal J.en_ZA
dc.contributor.authorThompson, Ethanen_ZA
dc.contributor.authorDowning, Katrinaen_ZA
dc.contributor.authorSuliman, Saraen_ZA
dc.contributor.authorMayanja-Kizza, Harrieten_ZA
dc.contributor.authorBoom, W. Henryen_ZA
dc.contributor.authorThiel, Bonnieen_ZA
dc.contributor.authorWeiner III, Januaryen_ZA
dc.contributor.authorKaufmann, Stefan H. E.en_ZA
dc.contributor.authorDover, Drewen_ZA
dc.contributor.authorTabb, David L.en_ZA
dc.contributor.authorDockrell, Hazel M.en_ZA
dc.contributor.authorOttenhoff, Tom H. M.en_ZA
dc.contributor.authorTromp, Gerarden_ZA
dc.contributor.authorScriba, Thomas J.en_ZA
dc.contributor.authorZak, Daniel E.en_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorGC6-74 Consortiumen_ZA
dc.date.accessioned2019-09-23T13:45:31Z
dc.date.available2019-09-23T13:45:31Z
dc.date.issued2018
dc.descriptionCITATION: Duffy, F. J., et al. 2018. A serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contacts. Frontiers in Immunology, 9:661, doi:10.3389/fimmu.2018.00661.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractENGLISH ABSTRACT: Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miRNAs) have been developed as biomarkers for other diseases. We performed machine-learning analysis of c-miRNA measurements in the serum of adult household contacts (HHCs) of TB index cases from South Africa and Uganda and developed a c-miRNA-based signature of risk for progression to active TB. This c-miRNA-based signature significantly discriminated HHCs within 6 months of progression to active disease from HHCs that remained healthy in an independent test set [ROC area under the ROC curve (AUC) 0.74, progressors < 6 Mo to active TB and ROC AUC 0.66, up to 24 Mo to active TB], and complements the predictions of a previous cellular mRNA-based signature of TB risk.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.00661/full
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationDuffy, F. J., et al. 2018. A serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contacts. Frontiers in Immunology, 9:661, doi:10.3389/fimmu.2018.00661
dc.identifier.issn1664-3224 (online)
dc.identifier.otherdoi:10.3389/fimmu.2018.00661
dc.identifier.urihttp://hdl.handle.net/10019.1/106518
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosisen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectMachine learningen_ZA
dc.subjectSerumen_ZA
dc.titleA serum circulating miRNA signature for short-term risk of progression to active tuberculosis among household contactsen_ZA
dc.typeArticleen_ZA
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