Inhaled beta-stimulants - a study of high-dose v. conventional-dose treatment in asthmatic outpatients
| dc.contributor.author | Bardin, P. G. | en_ZA |
| dc.contributor.author | Joubert, J. R. | en_ZA |
| dc.date.accessioned | 2011-03-18T14:57:18Z | |
| dc.date.available | 2011-03-18T14:57:18Z | |
| dc.date.issued | 1991 | |
| dc.description | CITATION: Bardin, P. G. & Joubert, J. R. 1991. Inhaled beta-stimulants - a study of high-dose v. conventional-dose treatment in asthmatic outpatients. South African Medical Journal, 79:655-659. | |
| dc.description | The original publication is available at http://www.samj.org.za | |
| dc.description.abstract | A randomised double-blind controlled trial was conducted in order to compare pulmonary function and protective effects of salbutamol 200 μg v. 1000 μg by inhalation. Twenty-three known asthmatics took part in the study for a period of 12 weeks. Pulmonary function tests were performed at home (peak expiratory flow-rate (PEFR)) and in the laboratory (vital capacity (VC), forced expiratory volume in 1 second (FEV1) and PEFR) before and after treatment. Bronchial responsiveness was measured as the provocative dose of histamine that caused a decrease of 30% of the area under the flow-volume curve (AFVE30) 90 minutes after pre-treatment with the study medication. The 20 patients (10 per treatment group) who completed the study were comparable at base-line in respect of physiological and pulmonary function measurements. Median PEFR, FVC and FVC1 did not differ between the treatment groups for the duration of study. Histamine challenge testing demonstrated a significant decrease in protection that was only seen after 8 weeks of treatment in the high-dose group (P < 0,05). Changes in pulse rate, blood pressure as well as side-effects were similar in the two groups. Thus treatment with higher doses of β-stimulants in outpatients had no demonstrable advantage. A significant impairment of the ability to protect against histamine-induced bronchoconstriction was shown; this may relate to β-receptor down-regulation and hence the development of tachyphylaxis. | |
| dc.description.version | Publisher’s version | |
| dc.format.extent | 5 pages | |
| dc.identifier.issn | 2078-5135 (online) | |
| dc.identifier.issn | 0256-9574 (print) | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/7322 | |
| dc.language.iso | en | |
| dc.publisher | Health & Medical Publishing Group | |
| dc.rights.holder | South African Medical Journal | |
| dc.subject | Asthma -- Treatment | en_ZA |
| dc.title | Inhaled beta-stimulants - a study of high-dose v. conventional-dose treatment in asthmatic outpatients | en_ZA |
| dc.type | Article |
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