Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy

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dc.contributor.authorGoodman, Megan B.en_ZA
dc.contributor.authorZiskind, Arien_ZA
dc.date.accessioned2016-08-19T09:58:52Z
dc.date.available2016-08-19T09:58:52Z
dc.date.issued2015-08-21
dc.descriptionCITATION: Goodman, M. B. & Ziskind, A. 2015. Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy. African Vision and Eye Health, 74(1), Art. #297, doi:10.4102/aveh.v74i1.297.
dc.descriptionThe original publication is available at http://www.avehjournal.org
dc.description.abstractPurpose: To determine the sensitivity of spectral domain ocular coherence tomography (SD-OCT) and fundus auto fluorescence (FAF) images as a screening test to detect early changes in the retina prior to the onset of chloroquine retinopathy. Method: The study was conducted using patients taking chloroquine (CQ), referred by the Rheumatology Department to the Ophthalmology Department at Tygerberg Academic Hospital. Group A consisted of 59 patients on CQ for less than 5 years, and Group B consisted of 53 patients on CQ for more than 5 years. A 200 × 200 macula thickness map, 5-line raster SD-OCT on a Carl Zeiss Meditec Cirrus HD-OCT and FAF images on a Carl Zeiss Meditec Visucam 500 were recorded for 223 eyes. Images were reviewed independently, and then those of Groups A and B compared. Results: There were no statistically significant differences between Groups A and B. The criteria included the internal limiting membrane and the retinal pigment epithelium (ILM-RPE) thickness, interdigitation zone integrity (p = 0.891, df = 1, χ² = 0.1876), ellipsoid zone integrity (p = 0.095, df = 2, χ² = 4.699) and FAF image irregularities (p = 0.479, df = 1, χ² = 4995978). Conclusion: The inclusion of SD-OCT and FAF as objective tests into the prescribed screening guidelines does not appear to simplify the detection of subclinical injury in patients on chloroquine treatment.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttp://www.avehjournal.org/index.php/aveh/article/view/297
dc.description.versionPublisher's version
dc.format.extent5 pagesen_ZA
dc.identifier.citationGoodman, M. B. & Ziskind, A. 2015. Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy. African Vision and Eye Health, 74(1), Art. #297, doi:10.4102/aveh.v74i1.297.
dc.identifier.issn2410-1516 (online)
dc.identifier.issn2413-3183 (print)
dc.identifier.otherdoi:10.4102/aveh.v74i1.297
dc.identifier.urihttp://hdl.handle.net/10019.1/99418
dc.language.isoen_ZAen_ZA
dc.publisherAOSIS Publishingen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectChloroquine retinopathyen_ZA
dc.subjectSpectral domain ocular coherence tomographyen_ZA
dc.subjectRetinopathy of prematurityen_ZA
dc.subjectFundus fluorescence photographyen_ZA
dc.titleFundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathyen_ZA
dc.typeArticleen_ZA
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