Haematological profile of chronic kidney disease in a mixed-ancestry South African population : a crosssectional study

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dc.contributor.authorGeorge, Cindyen_ZA
dc.contributor.authorMatsha, Tandi E.en_ZA
dc.contributor.authorErasmus, Rajiv T.en_ZA
dc.contributor.authorKengne, Andre P.en_ZA
dc.date.accessioned2019-10-22T13:09:21Z
dc.date.available2019-10-22T13:09:21Z
dc.date.issued2018-11
dc.descriptionCITATION: George, C., Matsha, T.E., Erasmus, R.T. & Kengne, A.P. 2018. Haematological profile of chronic kidney disease in a mixed-ancestry South African population: a crosssectional study. BMJ Open 8(11):e025694. doi:10.1136/bmjopen-2018-025694.en_ZA
dc.descriptionThe original publication is available at https://bmjopen.bmj.com/en_ZA
dc.description.abstractObjectives The objectives were to characterise the haematological profile of screen-detected chronic kidney disease (CKD) participants and to correlate the complete blood count measures with the commonly advocated kidney function estimators. Methods The current cross-sectional study used data, collected between February 2015 and November 2016, of 1564 adults of mixed-ancestry, who participated in the Cape Town Vascular and Metabolic Health study. Kidney function was estimated using the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, and anaemia as haemoglobin level <13.5 g/dL (men) and <12 g/dL (women). Results Based on the MDRD and CKD-EPI equations, the crude prevalence of CKD was 6% and 3%. Irrespective of the equation used, median red blood cell (RBC) indices were consistently lower in those with CKD compared with those without CKD (all p<0.0001). Despite not showing any significant difference in total white blood cell (WBC) count between the two groups, the number of lymphocytes were lower (p=0.0001 and p<0.0001 for MDRD and CKDEPI, respectively) and neutrophil count (both p<0.0297) and the ratio of lymphocytes to neutrophil (both p<0.0001) higher in the CKD group compared with those without CKD; with the remaining WBC indices similar in the two groups. The platelet count was similar in both groups. Of the screen-detected CKD participants, 45.5% (MDRD) and 57.8% (CKD-EPI) were anaemic, with the prevalence increasing with increasing severity of CKD, from 37.2% (stage 3) to 82.4% (stages 4–5). Furthermore, CKD-EPIestimated kidney function, but not MDRD, was positively associated with RBC indices. Conclusion Though it remains unclear whether common kidney function estimators provide accurate estimates of CKD in Africans, the correlation of their estimates with deteriorating RBC profile, suggests that advocated estimators, to some extent approximate kidney function in African populations.en_ZA
dc.description.sponsorshipSouth African Medical Research Council -- SAMRCen_ZA
dc.description.sponsorshipEconomic Competitiveness and Support Package (MRC-RFA-UFSP-01-2013/VMH Study)en_ZA
dc.description.sponsorshipNational Treasuryen_ZA
dc.description.versionPublishers versionen_ZA
dc.identifier.citationGeorge, C., Matsha, T.E., Erasmus, R.T. & Kengne, A.P. 2018. Haematological profile of chronic kidney disease in a mixed-ancestry South African population: a crosssectional study. BMJ Open 8(11):e025694. doi:10.1136/bmjopen-2018-025694.en_ZA
dc.identifier.issn2044-6055 (online)
dc.identifier.otherdoi:10.1136/bmjopen-2018-025694
dc.identifier.urihttp://hdl.handle.net/10019.1/106698
dc.language.isoen_ZAen_ZA
dc.publisherBMJ Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectKidney diseaseen_ZA
dc.subjectChronic kidney disease -- CKDen_ZA
dc.subjectKidney functionen_ZA
dc.subjectSouth African populationen_ZA
dc.subjectMixed-ancestryen_ZA
dc.subjectCape Town Vascularen_ZA
dc.subjectMetabolic health studyen_ZA
dc.subjectChronic Kidney Disease Epidemiology Collaboration -- CKD-EPIen_ZA
dc.subjectModification of Diet in Renal Disease -- MDRDen_ZA
dc.titleHaematological profile of chronic kidney disease in a mixed-ancestry South African population : a crosssectional studyen_ZA
dc.typeArticleen_ZA
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