Immune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis

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dc.contributor.authorHon, G.
dc.contributor.authorHassan, M.
dc.contributor.authorVan Rensburg, S. J.
dc.contributor.authorAbel, S.
dc.contributor.authorMarais, D. W.
dc.contributor.authorVan Jaarsveld, P.
dc.contributor.authorSmuts, C.
dc.contributor.authorHenning, F.
dc.contributor.authorErasmus, R.
dc.contributor.authorMatsha, T.
dc.date.accessioned2011-05-15T16:15:47Z
dc.date.available2011-05-15T16:15:47Z
dc.date.issued2009
dc.description.abstractMeasurement of fatty acids in biological fluids and cell membranes including leucocytes from multiple sclerosis patients is inconsistent. The objective of the present study was to investigate the fatty acid composition within the different membrane phospholipid fractions in peripheral blood mononuclear cells in multiple sclerosis patients, and correlate with severity of neurological outcome as measured by the Kurtzke Expanded Disability Status Scale and Functional System Scores. The fatty acid composition of phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin and phosphatidylinositol phospholipids in the peripheral blood mononuclear cells of twenty-six multiple sclerosis and twenty-five control subjects were measured by GC, and C-reactive protein was measured in all subjects. The elongation product of 20:4n-6, 22:4n-6, was significantly decreased in membrane phosphatidylethanolamine and phosphatidylserine in multiple sclerosis patients (P=0.01 and P=0.03 respectively), and correlated inversely with severity of disease and C-reactive protein. Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20:4n-6. Cultural and ethnic differences, as well as dietary variability, especially in a diseased state have been implicated in the differences observed in the fatty acid composition in peripheral blood mononuclear cell membranes of patients with multiple sclerosis. The present results suggest that the disease state may in part explain the reported inconsistencies in fatty acid levels in multiple sclerosis patients.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Nutrition
dc.identifier.citation102
dc.identifier.citation9
dc.identifier.issn00071145
dc.identifier.other10.1017/S0007114509382185
dc.identifier.urihttp://hdl.handle.net/10019.1/13489
dc.subjectC reactive protein
dc.subjectfatty acid
dc.subjectmembrane phospholipid
dc.subjectphosphatidylcholine
dc.subjectphosphatidylethanolamine
dc.subjectphosphatidylinositol
dc.subjectphosphatidylserine
dc.subjectsphingomyelin
dc.subjectautacoid
dc.subjectbiological marker
dc.subjectmembrane lipid
dc.subjectomega 3 fatty acid
dc.subjectomega 6 fatty acid
dc.subjectadult
dc.subjectarticle
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcultural factor
dc.subjectdiet
dc.subjectdisease severity
dc.subjectethnic difference
dc.subjectExpanded Disability Status Scale
dc.subjectfemale
dc.subjecthuman
dc.subjectlipid composition
dc.subjectmultiple sclerosis
dc.subjectperipheral blood mononuclear cell
dc.subjectblood
dc.subjectdisability
dc.subjecthospitalization
dc.subjectmale
dc.subjectmetabolism
dc.subjectmethodology
dc.subjectmiddle aged
dc.subjectmononuclear cell
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectBlood Specimen Collection
dc.subjectC-Reactive Protein
dc.subjectDisability Evaluation
dc.subjectFatty Acids
dc.subjectFatty Acids, Omega-3
dc.subjectFatty Acids, Omega-6
dc.subjectFemale
dc.subjectHumans
dc.subjectInflammation Mediators
dc.subjectLeukocytes, Mononuclear
dc.subjectMale
dc.subjectMembrane Lipids
dc.subjectMiddle Aged
dc.subjectMultiple Sclerosis, Relapsing-Remitting
dc.subjectSeverity of Illness Index
dc.titleImmune cell membrane fatty acids and inflammatory marker, C-reactive protein, in patients with multiple sclerosis
dc.typeArticle
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