dc.contributor.author	Ruiz-Herrera, Aurora
dc.contributor.author	Castresana, Jose
dc.contributor.author	Robinson, Terence J.
dc.date.accessioned	2010-12-14T13:33:10Z
dc.date.available	2010-12-14T13:33:10Z
dc.date.issued	2006-12
dc.date.updated	2010-11-09T12:56:56Z
dc.description	Includes bibliography.
dc.description.abstract	Background: A fundamental question in comparative genomics concerns the identification of mechanisms that underpin chromosomal change. In an attempt to shed light on the dynamics of mammalian genome evolution, we analyzed the distribution of syntenic blocks, evolutionary breakpoint regions, and evolutionary breakpoints taken from public databases available for seven eutherian species (mouse, rat, cattle, dog, pig, cat, and horse) and the chicken, and examined these for correspondence with human fragile sites and tandem repeats. Results: Our results confirm previous investigations that showed the presence of chromosomal regions in the human genome that have been repeatedly used as illustrated by a high breakpoint accumulation in certain chromosomes and chromosomal bands. We show, however, that there is a striking correspondence between fragile site location, the positions of evolutionary breakpoints, and the distribution of tandem repeats throughout the human genome, which similarly reflect a non-uniform pattern of occurrence. Conclusion: These observations provide further evidence that certain chromosomal regions in the human genome have been repeatedly used in the evolutionary process. As a consequence, the genome is a composite of fragile regions prone to reorganization that have been conserved in different lineages, and genomic tracts that do not exhibit the same levels of evolutionary plasticity.	en
dc.description.version	Peer reviewed
dc.format.extent	16 p. : ill
dc.identifier.citation	Ruiz-Herrera, A, Castresana, J & Robinson TJ 2006, 'Is mammalian chromosomal evolution driven by regions of genome fragility?', Genome Biology, 7(12):R115.
dc.identifier.issn	1465-6906 (printed)
dc.identifier.issn	1465-6914 (online)
dc.identifier.other	http://dx.doi.org/10.1186/gb-2006-7-12-r115
dc.identifier.uri	http://hdl.handle.net/10019.1/5118
dc.language.iso	en_ZA
dc.language.rfc3066
dc.publisher	BioMed Central
dc.rights.holder	Ruiz-Herrera et al.; licensee BioMed Central Ltd.
dc.subject	Genomics	en
dc.subject	Chromosomal change	en
dc.subject	Mammalian genome evolution	en
dc.subject	Mammals -- Genetics	en
dc.subject	Chromosomes	en
dc.title	Is mammalian chromosomal evolution driven by regions of genome fragility?	en
dc.type	Article

Is mammalian chromosomal evolution driven by regions of genome fragility?

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