Shorter telomere length : a potential susceptibility factor for HIV-associated neurocognitive impairments in South African woman

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dc.contributor.authorMalan-Muller, Stefanie
dc.contributor.authorHemmings, Sian M. J.
dc.contributor.authorSpies, Georgina
dc.contributor.authorKidd, Martin
dc.contributor.authorFennema-Notestine, Christine
dc.contributor.authorSeedat, Soraya
dc.date.accessioned2013-04-29T12:54:20Z
dc.date.available2013-04-29T12:54:20Z
dc.date.issued2013-03
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.descriptionThe original publication is available at http://www.plosone.org/en_ZA
dc.description.abstractThe neuropathogenesis of the human immunodeficiency virus (HIV) may manifest as various neurocognitive impairments (NCI). HIV-positive individuals also have significantly shorter telomere length (TL) in peripheral blood mononuclear cells (PBMCs) and CD8+ T cells compared to HIV-negative individuals. Additionally, reduced TL has been found to be associated with chronic psychological stress. This study focused on the effects of HIV-infection and chronic stress associated with childhood trauma on telomere length, and investigated whether leukocyte TL (LTL), in particular, represents a risk factor for NCI. Eighty-three HIV-positive and 45 HIV-negative women were assessed for childhood trauma and were subjected to detailed neurocognitive testing. Blood from each participant was used to extract Deoxyribonucleic acid (DNA). Relative LTL were determined by performing real time quantitative PCR reactions as described by Cawthon et al. (2002). As expected, relative LTL in the HIV-positive individuals was significantly shorter than that of HIV-negative individuals (F = 51.56, p=,0.01). Notably, a significant positive correlation was evident between relative LTL and learning performance in the HIVpositive group. In addition, a significant negative correlation was observed between relative LTL and verbal fluency, but this association was only evident in HIV-positive individuals who had experienced trauma. Our results suggest that reduced LTL is associated with worse learning performance in HIV-positive individuals, indicating that TL could act as a susceptibility factor in increasing neurocognitive decline in HIV-infected individuals.en_ZA
dc.description.sponsorshipStellenbosch University Open Access Funden_ZA
dc.description.versionPublishers' versionen_ZA
dc.format.extent8 p. : ill.
dc.identifier.citationMalan-Muller, S. et al. 2013. Shorter telomere length : a potential susceptibility factor for HIV-associated neurocognitive impairments in South African woman. PLoS One, 8(3):1-8, doi:10.1371/journal.pone.0058351.en_ZA
dc.identifier.issn1932-6203 (print)
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0058351
dc.identifier.urihttp://hdl.handle.net/10019.1/80703
dc.language.isoen_ZAen_ZA
dc.publisherPLoSen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTelomereen_ZA
dc.subjectHIV infections -- Psychological aspectsen_ZA
dc.subjectAIDS (Disease) in women -- Psychological aspectsen_ZA
dc.titleShorter telomere length : a potential susceptibility factor for HIV-associated neurocognitive impairments in South African womanen_ZA
dc.typeArticleen_ZA
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