Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor

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dc.contributor.authorMartin, C. J.en_ZA
dc.contributor.authorVeldman, F. J.en_ZA
dc.contributor.authorLabadarios, Demetreen_ZA
dc.contributor.authorEbrahim, Z.en_ZA
dc.contributor.authorMuller, E.en_ZA
dc.contributor.authorKassier, S. M.en_ZA
dc.date.accessioned2023-04-05T06:46:30Z
dc.date.available2023-04-05T06:46:30Z
dc.date.issued2021-06
dc.descriptionCITATION: Martin, C. J. et al. 2021. Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor. Scientific Reports, 11:12592, doi:10.1038/s41598-021-92016-2.
dc.descriptionThe original publication is available at https://www.nature.com
dc.description.abstractGastrointestinal symptoms (GIS) are common in kidney transplant candidates and recipients and may be worsened by HIV. Objective: To determine the frequency and severity of GIS in HIV-positive kidney transplant recipients from HIV-positive donors, and those waiting to receive one. A GIS rating scale (GSRS) was completed by 76 participants at baseline and at 6 months. GIS frequency was defined as having at least one symptom (GSRS > 1). Severity was indicated by the GSRS score. Transplant candidates: GIS frequency was 88.9% and 86.3% at baseline and 6 months respectively. Indigestion was the most frequent (79.6% and 66.7% at baseline and 6 months), and severe GIS (GSRS 2.3). Women reported global mean (p = 0.030) severity significantly more than men. Transplant recipients: GIS frequency was 95.2% and 76.2% at baseline and 6 months respectively. At both assessment points, indigestion occurred most frequently (85.7% and 61.9% respectively). Highest GSRS was reported for indigestion at baseline (2.33) and at 6 months (1.33). Waist circumference (WC) was positively associated with the severity of constipation GSRS. GIS are common in both groups, especially indigestions. WC in transplant recipients should be monitored.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-021-92016-2
dc.description.versionPublisher's version
dc.format.extent11 pages : illustrations
dc.identifier.citationMartin, C. J. et al. 2021. Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor. Scientific Reports, 11:12592, doi:10.1038/s41598-021-92016-2.
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi:10.1038/s41598-021-92016-2
dc.identifier.urihttp://hdl.handle.net/10019.1/126771
dc.language.isoen_ZAen_ZA
dc.publisherNature
dc.rights.holderAuthors retain copyright
dc.subjectKidneys -- Transplantationen_ZA
dc.subjectGastrointestinal system -- Diseasesen_ZA
dc.subjectOrgan donorsen_ZA
dc.subjectHIV-positive personsen_ZA
dc.titleGastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donoren_ZA
dc.typeArticleen_ZA
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