General movements in the perinatal period and its relation to echogenicity changes in the brain

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dc.contributor.authorRosier-van Dunne F.M.
dc.contributor.authorvan Wezel-Meijler G.
dc.contributor.authorBakker M.P.
dc.contributor.authorde Groot L.
dc.contributor.authorOdendaal H.J.
dc.contributor.authorde Vries J.I.
dc.date.accessioned2011-05-15T16:16:16Z
dc.date.available2011-05-15T16:16:16Z
dc.date.issued2010
dc.description.abstractBackground: In preterm born infants abnormal general movements (GMs) generally normalize before three months post term, but may persist when perinatal brain injury is present. Aims: To assess the continuity of GM quality from fetal to early neonatal period and its relation to brain echogenicity changes. Study design: Prospective study examining GMs and three vulnerable brain areas before and 7 days after birth. The quality of GMs was classified as normal or abnormal by Gestalt-perception. The brain was examined for moderate echogenicity changes (periventricular: brighter than choroid plexus, intraventricular: filling equal or more than 50% of the ventricle, and locally increased basal ganglia/thalami). Subjects: 94 fetuses from pregnancies complicated by preterm hypertensive disorders or labour at a gestational age between 26 and 34 weeks. Outcomes measures: Correlations of fetal GMs, echogenicity changes, and clinical parameters (e.g. gestational age, parity, hypertensive disorders or preterm labour, oligohydramnios and fetal growth restriction) with neonatal GMs. Results: Fetal GMs were abnormal in 64%, normalizing in 68% within 7 days after birth. Fetal GMs were significantly related to postnatal GMs (p = 0.045). Moderate fetal brain echogenicity changes and clinical parameters were not significantly related to neonatal GM. Conclusions: In this population of pregnancies compromised by hypertensive disorders or preterm labour fetal GMs correlated with neonatal GMs. Presence of moderate echogenicity changes in the fetal brain was not related to neonatal GMs. © 2010 Elsevier Ltd. All rights reserved.
dc.description.versionArticle
dc.identifier.citationEarly Human Development
dc.identifier.citation86
dc.identifier.citation2
dc.identifier.issn03783782
dc.identifier.other10.1016/j.earlhumdev.2010.01.023
dc.identifier.urihttp://hdl.handle.net/10019.1/13704
dc.subjectarticle
dc.subjectbasal ganglion
dc.subjectbody movement
dc.subjectbrain
dc.subjectbrain ventricle
dc.subjectchoroid plexus
dc.subjectembryo
dc.subjectfemale
dc.subjectfetus movement
dc.subjectgestational age
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmaternal hypertension
dc.subjectnewborn
dc.subjectperinatal period
dc.subjectprematurity
dc.subjectprospective study
dc.subjectthalamus
dc.subjectAdult
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectCerebral Ventricles
dc.subjectChoroid Plexus
dc.subjectEchoencephalography
dc.subjectFemale
dc.subjectFetal Movement
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectInfant, Premature
dc.subjectMale
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectPremature Birth
dc.subjectProspective Studies
dc.subjectPsychomotor Disorders
dc.subjectTime Factors
dc.subjectVideo Recording
dc.titleGeneral movements in the perinatal period and its relation to echogenicity changes in the brain
dc.typeArticle
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