Potentially modifiable factors associated with death of infants and children with severe pneumonia routinely managed in district hospitals in Malawi
| dc.contributor.author | Enarson, Penelope M. | en_ZA |
| dc.contributor.author | Gie, Robert P. | en_ZA |
| dc.contributor.author | Mwansambo, Charles C. | en_ZA |
| dc.contributor.author | Chalira, Alfred E. | en_ZA |
| dc.contributor.author | Lufesi, Norman N. | en_ZA |
| dc.contributor.author | Maganga, Ellubey R. | en_ZA |
| dc.contributor.author | Enarson, Donald A. | en_ZA |
| dc.contributor.author | Cameron, Neil A. | en_ZA |
| dc.contributor.author | Graham, Stephen M. | en_ZA |
| dc.date.accessioned | 2016-08-26T10:06:33Z | |
| dc.date.available | 2016-08-26T10:06:33Z | |
| dc.date.issued | 2015 | |
| dc.description | CITATION: Enarson, P. M., et al. 2015. Potentially modifiable factors associated with death of infants and children with severe pneumonia routinely managed in district hospitals in Malawi. PLoS ONE, 10(8):1-13, doi:10.1371/journal.pone.0133365. | |
| dc.description | The original publication is available at http://journals.plos.org/plosone | |
| dc.description.abstract | Objective: To investigate recognised co-morbidities and clinical management associated with inpatient pneumonia mortality in Malawian district hospitals. Methods: Prospective cohort study, of patient records, carried out in Malawi between 1st October 2000 and 30th June 2003. The study included all children aged 0-59 months admitted to the paediatric wards in sixteen district hospitals throughout Malawi with severe and very severe pneumonia. We compared individual factors between those that survived (n = 14 076) and those that died (n = 1 633). Results: From logistic regression analysis, predictors of death in hospital, adjusted for age, sex and severity grade included comorbid conditions of meningitis (OR =2.49, 95% CI 1.50-4.15), malnutrition (OR =2.37, 95% CI 1.94-2.88) and severe anaemia (OR =1.41, 95% CI 1.03-1.92). Requiring supplementary oxygen (OR =2.16, 95% CI 1.85-2.51) and intravenous fluids (OR =3.02, 95% CI 2.13-4.28) were associated with death while blood transfusion was no longer significant (OR =1.10, 95% CI 0.77-1.57) when the model included severe anaemia. Conclusions: This study identified a number of challenges to improve outcome for Malawian infants and children hospitalised with pneumonia. These included improved assessment of co-morbidities and more rigorous application of standard case management. | en_ZA |
| dc.description.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133365 | |
| dc.description.version | Publisher's version | |
| dc.format.extent | 13 pages | |
| dc.identifier.citation | Enarson, P. M., et al. 2015. Potentially modifiable factors associated with death of infants and children with severe pneumonia routinely managed in district hospitals in Malawi. PLoS ONE, 10(8):1-13, doi:10.1371/journal.pone.0133365 | |
| dc.identifier.issn | 1932-6203 (online) | |
| dc.identifier.other | doi:10.1371/journal.pone.0133365 | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/99482 | |
| dc.language.iso | en_ZA | en_ZA |
| dc.publisher | Public Library of Science | |
| dc.rights.holder | Authors retain copyright | |
| dc.subject | Pneumonia in children -- Malawi | en_ZA |
| dc.subject | Hospitals -- Malawi | en_ZA |
| dc.title | Potentially modifiable factors associated with death of infants and children with severe pneumonia routinely managed in district hospitals in Malawi | en_ZA |
| dc.type | Article | en_ZA |