Effects of combined administration of L-tryptophan and tricyclic antidepressants on α2- and β-adrenoceptors and monoamine levels in rat brain

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dc.contributor.authorRussell V.A.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorRussell V.A.
dc.contributor.authorLamm M.C.L.
dc.contributor.authorDe Villiers A.S.
dc.date.accessioned2011-05-15T16:17:29Z
dc.date.accessioned2011-05-15T16:17:29Z
dc.date.available2011-05-15T16:17:29Z
dc.date.available2011-05-15T16:17:29Z
dc.date.issued1985
dc.date.issued1985
dc.description.abstractIn order to test whether co-administration of a serotonin precursor with antidepressant drugs could potentiate the effects of the antidepressants on monoamines or adrenoceptors in rat brain, L-tryptophan (20 mg/kg) was administered to rats daily for 7 or 15 days, either alone or in combination with desipramine (10 mg/kg) or amitriptyline (10 mg/kg). After treatment with L-tryptophan for 7 days, increases were observed in rat hypothalamic and frontal cortex 5-hydroxy-3-indoleacetic acid levels as well as in hypothalamic dopamine and nucleus accumbens 3,4-dihydroxyphenylacetic acid levels. After 15 days, hippocampal β-adrenoceptor density was found to be decreased. There was no evidence of potentiation of desipramine or amitriptyline action when L-tryptophan was administered in combination with the antidepressants. On the contrary, the antidepressants appeared to interact with L-tryptophan to reduce its effects.
dc.description.abstractIn order to test whether co-administration of a serotonin precursor with antidepressant drugs could potentiate the effects of the antidepressants on monoamines or adrenoceptors in rat brain, L-tryptophan (20 mg/kg) was administered to rats daily for 7 or 15 days, either alone or in combination with desipramine (10 mg/kg) or amitriptyline (10 mg/kg). After treatment with L-tryptophan for 7 days, increases were observed in rat hypothalamic and frontal cortex 5-hydroxy-3-indoleacetic acid levels as well as in hypothalamic dopamine and nucleus accumbens 3,4-dihydroxyphenylacetic acid levels. After 15 days, hippocampal β-adrenoceptor density was found to be decreased. There was no evidence of potentiation of desipramine or amitriptyline action when L-tryptophan was administered in combination with the antidepressants. On the contrary, the antidepressants appeared to interact with L-tryptophan to reduce its effects.
dc.description.versionArticle
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation10
dc.identifier.citation12
dc.identifier.citationNeurochemical Research
dc.identifier.citation10
dc.identifier.citation12
dc.identifier.issn03643190
dc.identifier.issn03643190
dc.identifier.urihttp://hdl.handle.net/10019.1/14235
dc.identifier.urihttp://hdl.handle.net/10019.1/14235
dc.subjectalpha 2 adrenergic receptor; amitriptyline; beta adrenergic receptor; desipramine; monoamine; radioisotope; tricyclic antidepressant agent; tryptophan; 4 aminoclonidine h 3; animal cell; animal experiment; brain; central nervous system; dihydroalprenolol h 3; dopamine brain level; dose response; drug comparison; drug interaction; drug potentiation; drug receptor binding; drug response; intraperitoneal drug administration; nonhuman; pharmacokinetics; priority journal; rat; Amitriptyline; Animal; Antidepressive Agents, Tricyclic; Brain Chemistry; Catecholamines; Desipramine; Drug Combinations; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Support, Non-U.S. Gov't; Time Factors; Tryptophan
dc.subjectalpha 2 adrenergic receptor
dc.subjectamitriptyline
dc.subjectbeta adrenergic receptor
dc.subjectdesipramine
dc.subjectmonoamine
dc.subjectradioisotope
dc.subjecttricyclic antidepressant agent
dc.subjecttryptophan
dc.subject4 aminoclonidine h 3
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectbrain
dc.subjectcentral nervous system
dc.subjectdihydroalprenolol h 3
dc.subjectdopamine brain level
dc.subjectdose response
dc.subjectdrug comparison
dc.subjectdrug interaction
dc.subjectdrug potentiation
dc.subjectdrug receptor binding
dc.subjectdrug response
dc.subjectintraperitoneal drug administration
dc.subjectnonhuman
dc.subjectpharmacokinetics
dc.subjectpriority journal
dc.subjectrat
dc.subjectAmitriptyline
dc.subjectAnimal
dc.subjectAntidepressive Agents, Tricyclic
dc.subjectBrain Chemistry
dc.subjectCatecholamines
dc.subjectDesipramine
dc.subjectDrug Combinations
dc.subjectKinetics
dc.subjectMale
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Adrenergic, alpha
dc.subjectReceptors, Adrenergic, beta
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.subjectTryptophan
dc.titleEffects of combined administration of L-tryptophan and tricyclic antidepressants on α2- and β-adrenoceptors and monoamine levels in rat brain
dc.titleEffects of combined administration of L-tryptophan and tricyclic antidepressants on α2- and β-adrenoceptors and monoamine levels in rat brain
dc.typeArticle
dc.typeArticle
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