Platelet antibodies in immune thrombocytopenic purpura and onyalai

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dc.contributor.authorBrink, S.
dc.contributor.authorHesseling, P. B.
dc.contributor.authorAmadhila, S.
dc.contributor.authorVisser, H. S.
dc.date.accessioned2011-03-18T14:59:48Z
dc.date.accessioned2011-03-18T14:59:48Z
dc.date.available2011-03-18T14:59:48Z
dc.date.available2011-03-18T14:59:48Z
dc.date.issued1981
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractA prospective study was undertaken to assess the nature, incidence and natural history of platelet antibodies in patients with immune throbocytopenic purpura (ITP) and patients with onyalai, using an immunofluorescent technique. Twelve patients under 14 years old and 11 patients 14 - 75 years old with ITP, and 24 patients with onyalai were studied. Alternate younger patients were treated with corticosteroids. Ten of the 12 children with ITP had IgG platelet antibodies in their serum, which disappeared as the platelet count recovered. Steroid therapy did not change the course of the disease or the antibody response. Of the 24 patients with onyalai, 23 had IgG antibodies and 18 had IgM antibodies, which were still present after 14 days and unrelated to the rise in platelet count. Steroid therapy did not affect the platelet count or the antibody titre. The difference in immune response of ITP and onyalai points to a difference in aetiology. The clinical presence of IgM antibodies in onyalai fits the hypothesis that a toxin, possibly acting as a hapten, is responsible for this form of thrombocytopenia.en_ZA
dc.description.versionPublishers’ version
dc.format.extentpp. 855-858 : ill.
dc.identifier.citationS. Brink, S. Hesseling, P.B. S. Amadhila & H. S. Visser. 1981. Platelet antibodies in immune thrombocytopenic purpura and onyalei. South African medical Journal, 6 June 1981: 855-858.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.issn2078-5135 (online)
dc.identifier.urihttp://hdl.handle.net/10019.1/8061
dc.language.isoen_ZA
dc.publisherHMPG
dc.rights.holderThe author
dc.subjectThrombocyte antibodyen_ZA
dc.subjectAutoimmunityen_ZA
dc.subjectBlood and hemopoietic systemen_ZA
dc.subjectLymphatic systemen-ZA
dc.subjectOnyalaien_ZA
dc.subjectThrombocytopenic purpura -- Diagnosisen_ZA
dc.subjectBlood plateletsen_ZA
dc.subjectSteroid therapyen_ZA
dc.subjectImmunoglobulin Men_ZA
dc.subjectNutrition Disordersen_ZA
dc.subjectPurpura, Thrombocytopenicen_ZA
dc.subjectImmune thrombocytopenic purpuraen_ZA
dc.subjectCorticosteroids -- Treatmenten_ZA
dc.titlePlatelet antibodies in immune thrombocytopenic purpura and onyalaien_ZA
dc.typeArticleen_ZA
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