'n Ondersoek na die meganisme van delta-aminolevuliniensuur-neurotoksisiteit
| dc.contributor.author | Taljaard, J. J. F. | en_ZA |
| dc.contributor.author | Lamm, M. C. L. | en_ZA |
| dc.contributor.author | Truter, L. | en_ZA |
| dc.date.accessioned | 2011-03-18T14:57:47Z | |
| dc.date.available | 2011-03-18T14:57:47Z | |
| dc.date.issued | 1981 | |
| dc.description | The original publication is available at http://www.samj.org.za | |
| dc.description | CITATION: Taljaard, J. J. F., Lamm, M. C. L. & Truter, L. 1981. 'n Ondersoek na die meganisme van delta-aminolevuliniensuur-neurotoksisiteit. South African Medical Journal, 60:180-183. | |
| dc.description.abstract | The neurotoxicity of δ-aminolaevulinic acid (ALA), porphobilinogen (PBG), glutamic acid, γ-aminobutyric acid and kainic acid was compared in order to investigate the possibility of a common neurotoxic mechanism. Only ALA (10 μM) and glutamic acid (1 mM) were toxic towards neurons in culture, as measured by cell survival after 5 days' exposure. 3H-kainic acid binds to striatal membranes with an equilibrium dissociation constant (KD) of 57 nM and the number of binding sites was found to be 20 pmol/g striatal tissue. However, neither of the porphyrin precursors could displace kainic acid from these binding sites. Kainic acid alone caused neuronal degeneration after intrastriatal administration, as determined by 3H-spiroperidol binding to striatal membranes. The porphyrin precursors ALA and PBG thus do not share a common neurotoxic mechanism with the well-known neurotoxin kainic acid. | |
| dc.description.version | Publisher’s version | |
| dc.format.extent | 4 pages | |
| dc.identifier.issn | 2078-5135 (online) | |
| dc.identifier.issn | 0256-9574 (print) | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/7645 | |
| dc.language.iso | af | |
| dc.publisher | Health & Medical Publishing Group | |
| dc.rights.holder | South African Medical Journal | |
| dc.subject | Neurotoxicology | en_ZA |
| dc.title | 'n Ondersoek na die meganisme van delta-aminolevuliniensuur-neurotoksisiteit | af_ZA |
| dc.title.alternative | An investigation into the mechanism of delta-aminolaevulinic acid neurotoxicity | en_ZA |
| dc.type | Article |
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